NIH Releases Study on Big Data Collection and Identifying Emerging Disease Threats

A team of researchers at the National Institutes of Health (NIH) recently published a study in The Journal of Infectious Diseases on the impact big data, such as electronic health records and social media, could have on identifying emerging disease threats or potential outbreaks. Traditional infectious disease surveillance involves laboratory testing and data collected by public health institutions. However, this approach often leads to time lags and lacks the local resolution needed for accurate monitoring. Big data streams from internet queries have the benefit of speeding up a process, but can often come with its own biases on how a … Continue reading

Where Cells Go: Mechanical and Chemical Cues Collaborate to Guide Them

To create shear stress, the flow rate of the fluid moving across these cells was increased for 5 seconds. The cells sense the increased force and biochemical sensors move rapidly to the membrane in response. To see a VIDEO of these cells, click here. (Credit: Yulia Artemenko, Johns Hopkins Medicine) Living cells respond to biochemical signals by moving toward those at higher concentration, a process carefully mapped out by biologists over the past several decades. But cells also move in response to mechanical forces, such as bumping up against other objects — although the details of that action have been … Continue reading

NIH Team Identifies Potential Therapies for Drug-Resistant Bacteria

Researchers at the National Institutes of Health’s National Center for Advancing Translational Sciences (NCATS), Clinical Center and National Institute of Allergy and Infectious Diseases (NIAID) have created a new way to identify drugs and drug combinations that may potentially be useful in combating infections that are resistant to many different antibiotics. They developed an assay (test) to rapidly screen thousands of drugs to determine how effective they were against a variety of types of resistant bacteria. The screening method provides a potential new approach to repurpose known drugs and compounds to potentially help deal with powerful, hospital-borne infections, as well … Continue reading

Epic Update to “Candidate” Research Enrollment Status

Important information for all study team members The “candidate” research study enrollment status, in the Clinical Research Management System (CRMS), is being changed from a pre-consent status to an active status. As requested by study teams, this will allow the association of orders and encounters to research studies prior to patients being consented or enrolled in the study. Patients who are listed with a “candidate” enrollment status for a study will now display the Research Active indicator in their patient header. Study teams whose studies are already configured to receive ‘Research Pt ED/IP Admission’ In Basket notifications will now receive notifications … Continue reading

ICTR in the News: Elizabeth Jaffee Speaks at White House Press Briefing

On Oct. 24, the Johns Hopkins Institute for Clinical and Translational Research (ICTR)  and Johns Hopkins Kimmel Cancer Center’s deputy director, Elizabeth Jaffee, spoke at a White House press briefing about the Blue Ribbon Panel’s recommendations for Vice President Joe Biden’s Cancer Moonshot initiative. Read more about the Cancer Moonshot task force and the Blue Ribbon Panel’s recommendations for moving cancer research and treatment forward.

ICTR in the News: Nanofiber Coating Prevents Infections in Artificial Joints

This article, featured in “Proceedings of the National Academy of Sciences”, discusses research conducted by Lloyd Miller, Recipient of the Nexus Award for Innovations in Drug Delivery.   In a proof-of-concept study with mice, scientists at The Johns Hopkins University show that a novel coating they made with antibiotic-releasing nanofibers has the potential to better prevent at least some serious bacterial infections related to total joint replacement surgery. A report on the study, published online the week of Oct. 24 in Proceedings of the National Academy of Sciences, was conducted on the rodents’ knee joints, but, the researchers say, the technology would have … Continue reading

ICTR in the News: Simplified Study Aims to Quickly Test a Long-Shot ALS Treatment

This article features comments by Jeffrey Rothstein, ICTR Deputy Director. Researchers have launched an innovative medical experiment that’s designed to provide quick answers while meeting the needs of patients, rather than drug companies. Traditional studies can cost hundreds of millions of dollars, and can take many years. But patients with amyotrophic lateral sclerosis, or Lou Gehrig’s disease don’t have the time to wait. This progressive muscle-wasting disease is usually fatal within a few years. Scientists in an active online patient community identified a potential treatment and have started to gather data from the participants virtually rather than requiring many in-person … Continue reading

Funding Opportunity: Nexus Biomarkers and Diagnostic Testing Community

The Biomarkers and Diagnostic Testing Community of the Johns Hopkins Institute for Clinical and Translational Research is accepting applications for their Nexus Award Program.  The award strives to improve the research environment and career satisfaction of faculty by providing funds to investigators engaged in biomarker or diagnostic testing discovery and evaluation, including imaging research.  It is designed for investigators who wish to engage in short immersion experiences with colleagues at other academic research centers or industry partners. The award provides up to $25,000 including a maximum of $5,000 in travel, $200/day in support or replacement salary support. Applications are due … Continue reading

NCATS Funding Opportunity: Bench-to-Clinic Repurposing Initiative

NCATS anticipates awarding $3.5 million in fiscal year 2017 to fund up to 10 awards through a new Discovering New Therapeutic Uses for Existing Molecules (New Therapeutic Uses) Bench-to-Clinic Repurposing initiative. The goal is to support investigators to repurpose ― or identify new uses for — existing experimental drugs or biologics as well as Food and Drug Administration-approved therapies. Specifically, NCATS is seeking applications for pre-clinical (bench) studies to test the effectiveness of using an independent crowdsourcing effort, computational algorithm or big datasets from patient records to predict new uses of a drug or biologic. Based on recently awarded projects through a … Continue reading

ICTR Awarded NIH Grant for Innovation Center

The Johns Hopkins University School of Medicine won a 7-year, $25 million grant from the National Institutes of Health to form a trial innovation center with Tufts University School of Medicine. NIH’s National Center for Advancing Translational Sciences awarded the grant to Hopkins’ Brain Injury Outcomes program and its Institute for Clinical and Translational Research to develop a framework for studies conducted between different institutions by collaborating with Tufts. The Johns Hopkins University-Tufts Trial Innovation Center is one of three being set up. Others are being established at the University of Utah and with the pair of Duke and Vanderbilt … Continue reading

NCATS Funding Opportunity: Tissue Chip Program

NCATS has issued new funding opportunities through its Tissue Chip for Drug Screening program, including: Tissue Chips for Disease Modeling and Efficacy Testing: Letters of intent are due Oct. 29, 2016, and applications must be submitted by Dec. 13, 2016. Read the full announcement. Tissue Chips in Space: NCATS and the Center for the Advancement of Science in Space (CASIS) are collaborating to use tissue chip technology for translational research at the International Space Station U.S. National Laboratory. Letters of intent are due Nov. 15, 2016, and applications must be submitted by Dec. 15, 2016. Read the full announcement. In … Continue reading