Johns Hopkins Discovery Awards Given to 23 Cross-Divisional Research Teams

Funding is part of $15M commitment to cross-university, faculty-led research over three years. With support from Johns Hopkins University’s newDiscovery Awards, scholars will bridge medicine and engineering to create artificial lymph nodes, pair music and pharmacology to better understand treatments for depression and anxiety, and combine archaeology and materials science to understand artifacts from the ancient past. Twenty-three teams received word on Thursday that they were among the first chosen for the program, which will help them use the power of partnerships to fuel important discoveries and solve global challenges. All the teams are composed of members from at least … Continue reading

ICTR in the News: Link Between Disjointed Care and Unnecessary Medical Procedures

This article discusses research funded by the Institute for Clinical and Translational Research. Click here for a list of resources available to study teams. –Better “continuity of care” could significantly reduce overuse of medical tests such as preoperative chest X-rays A “look back” study of Medicare fee-for-service claims for more than 1.2 million patients over age 65 has directly affirmed and quantified a long-suspected link between lower rates of coordinated health care services and higher rates of unnecessary medical tests and procedures. In a report on the study published online May 18 in JAMA Internal Medicine, a trio of Johns … Continue reading

ICTR in the News: Carotid Stenting Warning

This article features study findings from former Clinical Research Scholar Mahmoud Malas. RE-INFLATING BALLOON AFTER CAROTID STENTING APPEARS TO DOUBLE RISK OF STROKE AND DEATH –Findings lead Johns Hopkins surgeons to call for end to routine “ballooning” once stent in place After reviewing outcomes from thousands of cases, researchers at Johns Hopkins report that patients with blocked neck arteries who undergo carotid stenting to prop open the narrowed blood vessels fare decidedly worse if their surgeons re-inflate a tiny balloon in the vessel after the mesh stent is in place. Although the overall risk of stroke and death is low … Continue reading

ICTR in the News: Novel Drug Improves Function of Cystic Fibrosis

A novel two-drug combination has the potential to target and restore a defective protein underlying cystic fibrosis (CF), according to two phase III clinical trials conducted at 187 medical centers around the world, including Johns Hopkins. The drug ivacaftor, in combination with an experimental medication called lumacaftor, led to modest improvements in lung function, but significant reductions in hospitalizations and antibiotics needed for lung infections. These results were published May 17 in the New England Journal of Medicine. The drug combination is intended for people 12 and up who have two copies of the most common CF mutation, called F508del. … Continue reading

ICTR in the News: The Role of 5-HT1A Receptors in Mediating Acute Negative Effects of Antidepressants

The findings of this study was published in the May 2015 edition of the Translational Psychiatry Journal. A portion of the statistical analyses was performed by the ICTR’s Biostatistics Center. Abstract: Acute antidepressant exposure elevates the frequency of impulsive behavior and suicidal thoughts in children and adolescents with major depressive disorder (MDD). Long-term antidepressant treatment, however, is beneficial for pediatric MDD, so it is necessary to explore novel treatments that prevent the potentially dangerous consequences of acute antidepressant initiation. In the present study, a treatment strategy designed to reverse the acute negative behavioral effects of antidepressants was tested in rodents. … Continue reading

Study Shows How Breast Milk Protects Against Severe Intestinal Disease in Preemies

The immune-boosting properties of breast milk have long been known. Now a team of scientists led by Johns Hopkins pediatric surgeon-in-chief David Hackam, M.D., Ph.D., says experiments in mice reveal how breast milk works to ward off the development of necrotizing enterocolitis (NEC), a devastating intestinal disorder that affects 12 percent of premature babies and claims the lives of one in four of those who have it. If affirmed in human studies, the experiments could pave the way to new preventive approaches to stave off NEC in premature babies and spark the development of treatments for those who develop the … Continue reading

PTSD Common in Intensive Care Unit Survivors

–Nearly one-quarter of intensive care unit survivors have post-traumatic stress disorder; diaries could be successful prevention tool Fast Facts Research finds that one-quarter of patients who survive a critical illness and an ICU stay experience PTSD. Researchers are looking into using ICU diaries as a promising therapeutic tool to prevent PTSD in ICU survivors. Existing psychological problems, large amounts of sedation and reports of frightening ICU memories appear to contribute to the increased risk of PTSD in ICU survivors. Post-traumatic stress disorder is often thought of as a symptom of warfare, major catastrophes and assault. It’s rarely considered in patients … Continue reading

Tumor-Only Genetic Sequencing May Misguide Cancer Treatment in Nearly Half of All Patients

–Johns Hopkins scientists say the genetic code of tumors must be compared to patients’ noncancer genome to get a true picture A study by Johns Hopkins scientists strongly suggests that sequencing tumor genomes for clues to genetic changes might misdirect treatment in nearly half of all patients unless it is compared first to a genetic readout of their noncancerous tissue. The investigators at the Johns Hopkins Kimmel Cancer Center say their analysis of more than 800 cancer patients’ sequencing data, which was generated by Personal Genome Diagnostics Inc., a company co-founded by the researchers, shows that without such comparisons, attempts … Continue reading

Johns Hopkins-Sun Yet sen Researchers Discover Autism Gender Differences

The article below was featured in Eureka Alert and discusses research findings from a study supported by a grant from Johns Hopkins Medicine International SYSU-JHU Pilot Grant Program on Clinical and Translational Research.   SAN DIEGO – Girls are diagnosed with autism spectrum disorder (ASD) later than boys, possibly because females exhibit less severe symptoms, according to a study to be presented Tuesday, April 28 at the Pediatric Academic Societies (PAS) annual meeting in San Diego. To study gender differences in age at diagnosis and compare symptom severity between boys and girls, researchers at the Kennedy Krieger Institute in Baltimore, MD, … Continue reading

ICTR Deputy Director Receives Excellence in Teaching Award

The article below honors Toby Gordon, ScD, ICTR Deputy Director of Business Strategies. Johns Hopkins Carey Business School Associate Professor Toby Gordon has been recognized with an Excellence in Teaching Award from students in the 2013-2015 cohort of the MBA/Master of Public Health dual-degree program offered by the Carey School and the Johns Hopkins Bloomberg School of Public Health. Gordon, who earned her ScD in health policy and management from the Bloomberg School, has expertise in the areas of health care policy, management of hospitals and health systems, and technology commercialization. She has joint appointments at the Bloomberg School and the … Continue reading

Successful Pharmaceutical Study Start-Up: Key Steps for New Investigators

Click here to register: Nearly 70% of clinical trials experience start-up delays, 45% are completed late, and 20% of sites recruit zero patients (Source: Centerwatch 2014). New Investigators: Don’t become a statistic! The Johns Hopkins Clinical Research Network invites you to attend Successful Pharmaceutical Study Start-Up: Key Steps for New Investigators. The seminar will take place on Monday, November 9, 2015 from 3:00 – 5:00 p.m., in the Tilghman Auditorium. Experts from the Office of Research Administration, Clinical Research Support Services, JHM IRB, ICTR, and the JHCRN will provide you with tips and tools to: * Improve efficiency in regulatory … Continue reading