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Attend the Johns Hopkins Biostatistics Center 20th Anniversary Showcase Dec 7


Highlighting 20 Years of Advancing Research and Practice at Johns Hopkins and Beyond The Johns Hopkins Biostatistics Center (JHBC) is hosting a showcase, Friday, December 7 beginning at 11:45 am in the Woods Basic Science Building. JHBC plans to share how they’ve collaborated to enhance the quality and efficiency of research and practice at JHMI. The showcase will feature 5 grand-rounds presentations with leading JHMI researchers and JHBC consultants demonstrating various statistical methods: design and analysis of multi-cohort survey data longitudinal data analysis in large observational studies analysis of complex hierarchically-structured data data management solutions multi-center clinical trials with unconventional … Continue reading

Study Affirms Challenges in Managing Severe Pain of Sickle Cell Disease


Findings underscore need to find alternatives and supplements to opioids, researchers say In a study tracking the severe crisis pain of sickle cell disease and its management in 73 adults over a period of a year, Johns Hopkins researchers found that even among those on high doses of daily at-home opioids, a persistent subset was more likely to seek emergency hospital care for crisis pain and was less likely to have the pain controlled by intensive treatment. The researchers say their findings, described in the September issue of the American Journal of Hematology, underscore the persistent difficulties, poor patient outcomes … Continue reading

Apply for the NCI SPRINT Program


        The National Cancer Institute (NCI)’s Speeding Research-tested INTerventions (SPRINT) program is designed to foster an innovation ecosystem for interventionists by providing real-world, hands-on training on how to transform innovations in cancer control into market-ready products and services. ELIGIBILITY NCI-funded investigators with either a currently active R01 grant (that is at least in year 2) or an R01 that was completed after January 1, 2014, are eligible to apply. The focus of the R01 grant must be on the design, testing, delivery, and/or implementation of an intervention or tool to advance cancer prevention and control. PROGRAM REQUIREMENTS … Continue reading

Researchers Advance Role of Circulating Tumor DNA to Detect Early Melanoma Growth


Researchers at the Johns Hopkins Kimmel Cancer Center say they have added to evidence that measuring and monitoring tumor DNA that naturally circulates in the blood of melanoma patients can not only reliably help reveal the early stages of cancer growth and spread but can also uncover new treatment options that tumor genetic analysis alone may not. “For some patients in our study, ctDNA (circulating tumor DNA) levels measured in a relatively simple blood test revealed tumor mutations that could be potentially targeted with current or new drugs that inhibit tumor growth mutations that are not revealed by genetic profiling … Continue reading

Dry Eye Syndrome Slows Reading Rate


Slow reading rate can significantly disrupt day to day tasks that require visual concentration for long periods of time. Johns Hopkins researchers report that chronic dry eye, a condition in which natural tears fail to adequately lubricate the eyes, can slow reading rate and significantly disrupt day to day tasks that require visual concentration for long periods of time. In a study of 186 adults, published online Nov. 15, in Optometry and Vision Science, dry eye specialists at Johns Hopkins Medicine say the condition can slow a person’s reading speed by as much as 10 percent and can make it … Continue reading

Decrease In Specific Gene ‘Silencing’ Molecules Linked with Pediatric Brain Cancer


Experimenting with lab-grown brain cancer cells, Johns Hopkins Medicine researchers have added to evidence that a shortage of specific tiny molecules that silence certain genes is linked to the development and growth of pediatric brain tumors known as low-grade gliomas. A report of the findings was published this fall 2018 in Scientific Reports, and supports the idea of increasing levels of microRNAs as a potential means of treating these tumors. An estimated 1,600 cases of pediatric low-grade gliomas (PLGGs) are diagnosed annually in the United States, and the vast majority of these slow-growing tumors are treatable and curable mainly by … Continue reading

Nasal Delivery of Weight-Loss Hormone Eases Breathing Probems


Researchers find that the hunger hormone leptin eases breathing problems in mice during sleep Experimenting with mice, Johns Hopkins Medicine researchers have added to evidence that a hormone best known for helping regulate hunger and body weight might also ease breathing problems experienced during sleep more effectively when given through the nose. Although clinical trials using the hormone, known as leptin, aren’t yet on the horizon, the investigators say their success delivering it through the test animals’ noses may help them develop easier-to-use therapies for people with sleep-related breathing problems such as sleep apnea. The findings were published online Oct. … Continue reading

Cell Death Pathway Tied to Parkinson’s Disease


ROAD TO CELL DEATH MORE CLEARLY IDENTIFIED FOR PARKINSON’S DISEASE –A pathway toward cellular death named for Thanatos, the ancient Greek personification of death, identified by researchers as a key driver of nerve cell degradation in Parkinson’s disease In experiments performed in mice, Johns Hopkins researchers report they have identified the cascade of cell death events leading to the physical and intellectual degeneration associated with Parkinson’s disease. Results of the study, published Nov. 2 in Science, suggest promising new targets for drugs that could interrupt Parkinson’s disease progression. The study, the researchers say, focused on Parthanatos, a specialized “programmed” pathway … Continue reading

Mutation Associated with ALS Causes Sugar-Starved Cells to Overproduce Lipids


Finding could lead to new ways to fight this and other neurodegenerative diseases, including dementia A genetic defect tied to a variety of neurodegenerative diseases and mental illnesses changes how cells starved of sugar metabolize fatty compounds known as lipids, a new study led by researchers from the Johns Hopkins Bloomberg School of Public Health shows. The finding could lead to new targets to treat these diseases, which currently have no cure or fully effective treatments. Taken together, these results suggest that the genetic defect, mutations in a gene called C9orf72, lead to greater amounts of a protein that causes … Continue reading

CD2H Show and Tell Webinar


Please join us! Show and Tell Webinar Featuring the CD2H Data Workgroup  November 2, 1-2 pm Eastern Time Register   This Show and Tell will feature current CD2H People Workgroup project leads sharing progress on their work. This will be a great opportunity for the CTSA community to learn about exciting work underway and provide valuable input and feedback. Workshop Leads: Melissa Haendel, PhD David Eichmann, PhD Kristi Holmes, PhD

Deep Brain Stimulation For Alzheimer’s Not For Everyone


Patients with late-onset Alzheimer’s may show some long-term benefit, but none for early-onset     In a report of the phase II ADvance clinical trial, Johns Hopkins researchers report that people diagnosed under age 65—those with early onset Alzheimer’s disease—didn’t benefit from deep brain stimulation. Their findings appeared in the July issue of the Journal of Alzheimer’s Disease “Our results suggest that as we look at deep brain stimulation as a treatment for Alzheimer’s disease, we should probably focus on those over 65, which is the bulk of people with Alzheimer’s,” says Jeannie-Marie Leoutsakos, Ph.D., associate professor of psychiatry and … Continue reading