ICTR in the News: Fentanyl Not Recommended For Routine Use During Coronary Angiographies

The following article contains contributions from ICTR researcher J. William McEvoy, M.B.B.Ch., M.H.S., assistant professor of medicine and member of the Ciccarone Center for the Prevention of Heart Disease at the Johns Hopkins University School of Medicine. In a randomized, double-blind, clinical trial of 212 patients, Johns Hopkins researchers have found that the routine use of fentanyl for sedation and comfort during coronary angiography reduces the effectiveness of the platelet blocking drug ticagrelor, and it doesn’t appear to provide any better pain relief than just local anesthesia. Fast-acting platelet blocking drugs such as ticagrelor are essential for preventing platelets from … Continue reading

ICTR in the News: Brain Scan Study Adds to Evidence That Lower Brain Serotonin Levels are Linked to Dementia

The following article profiles work performed by ICTR researcher Gwenn Smith, Ph.D., professor of psychiatry and behavioral sciences at the Johns Hopkins University School of Medicine and director of geriatric psychiatry and neuropsychiatry at Johns Hopkins University School of Medicine. Results suggest serotonin loss may be a key player in cognitive decline, not just a side-effect of Alzheimer’s disease In a study looking at brain scans of people with mild loss of thought and memory ability, Johns Hopkins researchers report evidence of lower levels of the serotonin transporter — a natural brain chemical that regulates mood, sleep and appetite. Previous … Continue reading

ICTR in the News: Prostate Cancer Cells Become ‘Shapeshifters’ to Spread to Distant Organs

The following article profiles work performed by ICTR researcher Vasan Yegnasubramanian, M.D., Ph.D., associate professor at the Kimmel Cancer Center. Johns Hopkins Kimmel Cancer Center scientists report they have discovered a biochemical process that gives prostate cancer cells the almost unnatural ability to change their shape, squeeze into other organs and take root in other parts of the body. The scientists say their cell culture and mouse studies of the process, which involves a cancer-related protein called AIM1, suggest potential ways to intercept or reverse the ability of cancers to metastasize, or spread. Results of the research are described in … Continue reading

Pharmaceutical Enterprise Course (ME:208.708)

This course begins Sept 1st. Contact Takashi Tsukamoto for more information. Pharmaceutical Enterprise is a discussion-driven and highly interactive course designed to provide students with greater insights into a range of topics related to the pharmaceutical enterprise. The course consists of seven modules, each of which begins with a pre-lecture discussion session proceeded by a lecture by an expert in the given subject, and post-lecture discussion session. This 3-segment format enables students to digest the topic thoroughly and gain in-depth knowledge through peer discussion and interaction with lecturers. The course is particularly suited for individuals interested to advance their career … Continue reading

Extinction Mystery Solved? Fossil Evidence Suggests Humans Played a Role in Monkey’s Demise in Jamaica

Radiocarbon dating of a fossilized leg bone from a Jamaican monkey called Xenothrix mcgregori suggests it may be the one of the most recent primate species anywhere in the world to become extinct, and it may solve a long-standing mystery about the cause of its demise. The short answer: human settlement of its island home. Though the team of specialists who conducted the study says its evidence is indirect, it is consistent with the idea that humans sped the species’ extinction through some combination of predation, competition for resources, habitat destruction and introduction of invasive species. “Understanding how this extinction … Continue reading

ICTR in the News: The Johns Hopkins Hospital Ranked Among the Top Three U.S. Adult Hospitals by U.S. News & World Report

The following article features contributions from ICTR researcher Redonda G. Miller, M.D., M.B.A., president of The Johns Hopkins Hospital. Named the #1 hospital in Maryland and #3 in the nation on the 2017–18 Best Hospitals list, making it the nation’s top-ranked hospital combined for both adult and pediatric care Out of nearly 4,700 hospitals reviewed, The Johns Hopkins Hospital ranked #1 in Maryland and #3 in the nation in U.S. News & World Report’s 2017–18 Best Hospitals list. Thirteen specialties at The Johns Hopkins Hospital are now among the top 10 in the nation. Ten specialties are in the top … Continue reading

ICTR in the News: Guidelines for Assessing Orthostatic Hypotension Should Be Changed, New Study Recommends

The following article profiles work performed by ICTR researcher Stephen Juraschek, M.D., Ph.D., a general internal medicine fellow at the Johns Hopkins University School of Medicine. A new study led by Johns Hopkins researchers suggests that testing for the presence of orthostatic hypotension, a form of low blood pressure, be performed within one minute of standing after a person has been lying down. Current guidelines recommend taking the measurement three minutes after a person stands up. “Our findings suggest that a blood pressure assessment within the first minute is a better way to assess health risks due to orthostatic hypotension … Continue reading

Johns Hopkins Researcher Available to Discuss Your Brain on the Arts

Our brains interpret the world around us, taking in the sights, sounds, textures and smells of the world. But how does our brain respond when we observe art? What goes on in its neural circuits when we see or create something beautiful? Susan Magsamen, executive director of the International Arts and Mind Lab of the Brain Science Institute at the Johns Hopkins University School of Medicine, is pioneering the effort to marry the arts and research to find answers to these questions. The answers and the quantifiable results seen in patients may turn medical and social interventions as we know … Continue reading

ICTR in the News: Study Adds to Evidence That Most Prescribed Opioid Pills Go Unused

The following article profiles work performed by ICTR researcher Mark Bicket, M.D., an assistant professor of anesthesiology and critical care at the Johns Hopkins University School of Medicine. In a review of half a dozen published studies in which patients self-reported use of opioids prescribed to them after surgery, researchers at Johns Hopkins report that a substantial majority of patients used only some or none of the pills, and more than 90 percent failed to dispose of the leftovers in recommended ways. A summary of the review, published August 2 in JAMA Surgery, highlights the need for more personalized pain … Continue reading

NCATS Hosts Local Assay Guidance Workshop

NCATS is hosting an Assay Guidance Workshop for High-Throughput Screening and Lead Discovery on Aug. 7, 2017, in Potomac, Maryland. The full-day workshop will cover a broad range of critical concepts underlying assay development for high-throughput screening and lead discovery projects. This workshop, which will feature presentations by several NCATS staff members, is designed to disseminate critical information about the implementation of robust assay methods and is particularly relevant for researchers developing bioassays for the discovery of drugs or chemical probes. Space is limited so register now. View the agenda. Learn more about the workshop.  

SPIRiT Consortium Awards Nearly $300,000 for Cross Country Research Collaborations

A funding partnership among seven prestigious universities – including the Johns Hopkins Institute for Clinical and Translational Research – are awarding nearly $300,000 to scientists working on collaborative research among their institutes that will explore widely ranging health concerns, from creating tumor-destroying viruses to decreasing the large numbers of mentally ill in the criminal justice system. The Sharing Partnership for Innovative Research in Translation (SPIRiT) consortium has offered this funding of research since 2012, awarding more than $1 million to 12 collaboration projects. The SPIRiT consortium is made up of six National Institutes of Health (NIH) Clinical and Translational Science … Continue reading