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‘Swiss Cheese’ Bones Could Be Cause of Unexplained Low Back Pain


Age-related changes to the cartilaginous tissue of the spine could invite painful nerve growth, say researchers In experiments with genetically engineered and old mice, Johns Hopkins Medicine researchers say they have added to evidence that the vast majority of low back pain in people may be rooted in an overgrowth of pain-sensing nerves into spinal cartilaginous tissue. An estimated 80% of people worldwide will experience low back pain in their lifetimes, sometimes owing to strain or injury. But the vast majority of low back pain, the researchers say, emerges in the absence of injury, especially in older age. The new […]

Surgery May Add Months or Years of Survival For Adults With Rare And Deadly Brain Cancers


Findings from medical records study could help doctors and patients make more informed treatment decisions Credit: Alicia Ortega, MS For adult patients with brainstem high-grade gliomas — one of the rarest and deadliest forms of brain cancer — surgically removing the entire tumor may add many months or potentially years of survival beyond that offered by radiation and chemotherapy, according to results of a medical records study led by researchers at the Johns Hopkins Kimmel Cancer Center. The investigators point out that survival for these tumors has remained poor, with a median survival length of eight months after diagnosis in […]

Apply for the Johns Hopkins Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) K12 Program by April 1


The Johns Hopkins Building Interdisciplinary Research Careers in Women’s Health (BIRCWH) K12 program is accepting applications for the 2020 cycle. BIRCWH was established to develop highly qualified, independent investigators to conduct women’s health and sex gender differences research. The program provides 3 core strength areas: diseases specific to women (e.g. women’s cancer and reproductive biology) sex and gender differences in disease expression (e.g. immunology, neuroscience, cardiovascular and genetics) social determinants of women’s health and disparities (e.g. violence against women, trauma, addictions and poverty) The award is expected to consist of salary support up to $100,000 (75% effort) and fringe and […]

Natural Herb Kratom May Have Therapeutic Effects And Relatively Low Potential For Abuse Or Harm, According To A User Survey


Researchers say findings underscore need for research and regulation, but not an outright ban on sales Using results of a survey of more than 2,700 self-reported users of the herbal supplement kratom, sold online and in smoke shops around the U.S., Johns Hopkins Medicine researchers conclude that the psychoactive compound somewhat similar to opioids likely has a lower rate of harm than prescription opioids for treating pain, anxiety, depression and addiction. In a report on the findings, published in the Feb. 3 issue of Drug and Alcohol Dependence, the researchers caution that while self-reporting surveys aren’t always entirely reliable, they […]

Some Learning is A Whole-Brain Affair, Study Shows


AMPA receptors in green on neurons in magenta at one time point in a live mouse. Credit: Richard Roth and Richard Huganir Researchers at Johns Hopkins Medicine have successfully used a laser-assisted imaging tool to “see” what happens in brain cells of mice learning to reach out and grab a pellet of food. Their experiments, they say, add to evidence that such motor-based learning can occur in multiple areas of the brain, even ones not typically associated with motor control. “Scientists should be looking at the entire brain to understand specific types of learning,” says Richard Huganir, Ph.D., Bloomberg Distinguished […]

Less-Than-Perfect Kidneys Can be Successfully Used For Transplants, Study Shows


Johns Hopkins Medicine-led study provides the strongest evidence to date that hundreds of deceased donor kidneys, discarded each year after being deemed not suitable under current medical criteria, can be transplanted safely and effectively. Based on its findings reported in the Jan. 8, 2020, issue of JAMA Network Open, the research team strongly recommends that harvested kidneys with acute kidney injury (AKI) no longer be rejected outright, in order to bolster efforts to reduce the drastic shortage of organs available for transplant in the United States. Currently, the national discard or rejection rate for all potential donor kidneys is approximately […]

Trial Suggests Babies in Intensive Care Can be Better Protected From Parental Bacteria


  For sick or prematurely born babies spending their first days of life in a hospital’s neonatal intensive care unit (NICU), the soothing voice and gentle touch of a loving parent can have a tremendous impact toward a positive outcome — that is, unless mom or dad’s visit leaves the infant with something extra: a dangerous bacterial infection. Now, a Johns Hopkins Medicine research team reports it has developed and tested a relatively simple strategy for reducing the chance of parents exposing their babies in the NICU to one of the most commonly diagnosed and potentially deadly microbial scourges in […]

Register for the 5th Annual Trends in Clinical Research Symposium March 12


Clinical Research by Learning from Practice: Facilitating through Technology and Collaboration   The Johns Hopkins Clinical Research Network (JHCRN) invites you to attend the 5th Annual Trends in Clinical Research Symposium, “Clinical Research by Learning from Clinical Practice: Facilitating through Technology and Collaboration”. Keynote speaker, James Williams, PhD, MHS, serves as the senior director for Global Networks – Medical Evidence, Research, and Innovation at Biogen. The day also includes a panel discussion featuring: Ellen Mowry, MD Associate Professor of Neurology Johns Hopkins School of Medicine Peter Zandi, PhD, MPH, MH Professor Johns Hopkins Bloomberg School of Public Health Diana Gumas, […]

CATALiST Seminar March 3- Computer Science and Medicine: The Twain Shall Meet!


Co-Sponsored by the Johns Hopkins & University of Maryland Baltimore Institutes for Clinical & Translational Research   To attend, contact Molly Lutz at 410-328-2488 or mlutz@som.umaryland.edu. Links: CATALiST Seminar Series  University of Maryland Baltimore Institute for Clinical and Translational Research      

Johns Hopkins All Children’s Hospital Researcher Plays Key Role toward Landmark FDA Drug Approval for Anticoagulant in Children


Venous thromboembolism (VTE) is a disorder that includes deep vein thrombosis and pulmonary embolism. A deep vein thrombosis (DVT) occurs when a blood clot forms in a deep vein, usually in the lower leg, thigh, or pelvis. A pulmonary embolism (PE) occurs when a clot breaks loose and travels through the bloodstream to the lungs. In 2008, Johns Hopkins professor of pediatrics and medicine Neil Goldenberg, MD, PhD (at the time, a faculty member of University of Colorado School of Medicine) submitted an investigator-initiated trial (IIT) award application to the pharmaceutical company that oversaw research and development of the low […]

Funding Opportunity: Johns Hopkins Older Americans Independence Center Awards, Deadline March 1


The deadline for proposals is Sunday, March 1 by 5 pm. The Johns Hopkins Claude D. Pepper Older Americans Independence Center (OAIC) is seeking proposals from faculty researchers for studies on frailty in older Americans, with discovery aimed at impacting the larger field of frailty science, as articulated in the attached requests for proposals. There are four award opportunities: Research Education Core Funding for Junior Faculty ($35,000 direct costs) Pilot/Exploratory Studies Core Funding ($30,000 direct costs) Biostatistics Core Development Project Funding ($35,000 direct costs) Biological Mechanisms Development Project Funding ($35.000 direct costs) Successful applicants will receive salary, research core support, […]