Tag Archive: Labs
Drug Screening, Development & Analysis Units
Posted by: Crystal Williams on: May 1, 2018
The Drug Screening Library Unit maintains, distributes, and screens drug library (FDA approved) compounds. This unit is ideal for re-purposing licensed drugs by screening activity against new targets. For more information, contact: Jun Liu, PhD Lab Leader 410-955-4619 | joliu@jhmi.edu The Drug Development Unit provides: Consultative support for early phase clinical drug development Protocol design and data analysis support Early phase clinical study support For more information, contact: Craig Hendrix, MD Lab Leader 410-955-9707 | chendrix@jhmi.edu The Drug Analysis Unit provides support for drug development activities to faculty and to solicit use by faculty of Core expertise and facilities. Activities include consultative … Continue reading
Evolutionary Biologists Say Recently Discovered Fossil Shows Transition of a Reptile From Life on Land to Life in the Sea
Posted by: Crystal Williams on: December 12, 2017
Using modern research tools on a 155-million-year-old reptile fossil, scientists at Johns Hopkins and the American Museum of Natural History report they have filled in some important clues to the evolution of animals that once roamed land and transitioned to life in the water. A report on the new discoveries about the reptile, Vadasaurus herzogi, appears online in the Nov. 8 issue of Royal Society Open Science, and suggests that some of the foot-long animal’s features, including its elongated, whip-like tail, and triangular-shaped head, are well suited to aquatic life, while its relatively large limbs link it to land-loving species. … Continue reading
Lab Resources
Posted by: Crystal Williams on: July 22, 2017
The ICTR laboratories provide coordinated help across several related programs, all focused on the foundational components required to effectively translate new drugs, biologics, vaccines, devices, biomarkers and diagnostics into clinical trials and eventually clinical practice.
Imaging Translational Program
Posted by: Crystal Williams on: August 7, 2014
The Imaging Translational Technology Core (Imaging TTC) facilitates one-on-one consultation with imaging experts for study design, imaging protocol development and study implementation. The core facilitates integrated use of imaging resources in translational projects and clinical trials and offers research imaging management infrastructure through the Johns Hopkins Medical Image Research Archive Center for research data storage and distribution Imaging also offers CORIS, a one week observership program for anyone interested in radiology. Participants have an opportunity to shadow Katarzyna (Kasia) J. Macura, MD, PhD, FACR, Professor of Radiology, Urology and Oncology. For more information and to schedule a time, contact Atefeh Ameri at … Continue reading
Proteomic Biomarker Development Program
Posted by: Crystal Williams on: August 7, 2014
Proteomics Facility couples mass spectrometry to one and two dimensional separations by column chromatography or gel electrophoresis to identify, quantify or characterize proteins and their post-translational modifications, that are present in complex protein extracts or isolated in solution, gel bands or spots from cells, tissues or body fluids. Metabolite profiling for small molecules from clinical samples Provides biomarker development support Marker verification, validation, qualification for clinical implementation Provides technology and analysis to maximizes coverage of key proteomes required for discovery Quantitative protein analysis methods including mass spectrometry and development of new technologies
Biologics Translational Program
Posted by: Crystal Williams on: August 7, 2014
This lab offers: Biologic product development and testing Consultative support for biologic development Preclinical testing to clinical production for early phase clinical testing Good Manufacturing Practices (GMP) facility and expertise to produce and maintain (stability testing Cell lines Gene vectors Antibodies Peptides Submit an ICTR Connection Request
Medicinal Chemistry Unit
Posted by: Crystal Williams on: August 7, 2014
The Medicinal Chemistry Unit synthesizes small molecule when it is not commercially available. This unit also supports structure-activity relationship studies. For more information, contact David Meyers, PhD at dmeyers7@jhmi.edu.
Genetics Translational Technology Program
Posted by: Crystal Williams on: January 7, 2014
The Genetics Translational Technology Program bridges the gap between clinical genetic testing and research-driven molecular technologies with consulting and laboratory services and assistance with translation of molecular technologies to the clinical environment. The program provides: A consultation for the development and conduct of genetic based sequencing and diagnostic assays for clinical testing Clinical assay development services Exome and whole genome sequencing using next generation sequencing (NGS) technologies Partnership with the Kennedy Krieger Institute’s Cytogenetics Laboratory for SNP Array Analysis ICTR Connection Request
Cardiovascular Imaging Laboratory
Posted by: Crystal Williams on: January 1, 2014
The Cardiovascular Imaging Laboratory provides echocardiographic and carotid imaging for approved CRU protocols, as well as measurement of endothelial function and arterial stiffness. The Cardiovascular Imaging Laboratory provides the following services and equipment: Echocardiogram Echocardiograms are performed on a Toshiba Artida ultrasound system. All cardiac studies are stored digitally and analyzed using the Philips Excelera System. Image acquisition and analysis protocols can be customized to meet the unique needs of the investigator. Carotid IMT Carotid imaging is performed on a Toshiba Aplio ultrasound system. Using commercially available state of the art equipment that includes automated border detection, the core lab … Continue reading
Clinical Research Unit Core Laboratory
Posted by: Crystal Williams on: January 1, 2014
Donna Boone spinning blood samples in the refrigerated centrifuge. The Clinical Research Unit Core Laboratory is housed in the Asthma and Allergy Center at the Bayview Medical Campus. The Core also includes a Sample Processing Laboratory located in the Bayview CRU on the fourth floor of the 301 Building. Directed by Neal Fedarko, PhD, a professor in the Division of Geriatric Medicine and Gerontology, the laboratory offers 87 distinct assays of clinical chemical endpoints and biomarkers to support ICTR research protocols. It is designed to serve ICTR investigators at all CRU locations. The ICTR CRU Core Laboratory supports ICTR-approved protocols … Continue reading