Tag Archive: LABS

Drug Screening, Development & Analysis Units


The Drug Screening Library Unit maintains, distributes, and screens drug library (FDA approved) compounds.  This unit is ideal for re-purposing licensed drugs by screening activity against new targets. For more information, contact: Jun Liu, PhD Lab Leader 410-955-4619 | joliu@jhmi.edu The Drug Development Unit provides: Consultative support for early phase clinical drug development Protocol design and data analysis support Early phase clinical study support For more information, contact: Craig Hendrix, MD Lab Leader 410-955-9707 | chendrix@jhmi.edu The Drug Analysis Unit provides support for drug development activities to faculty and to solicit use by faculty of Core expertise and facilities. Activities include consultative … Continue reading

Evolutionary Biologists Say Recently Discovered Fossil Shows Transition of a Reptile From Life on Land to Life in the Sea


Using modern research tools on a 155-million-year-old reptile fossil, scientists at Johns Hopkins and the American Museum of Natural History report they have filled in some important clues to the evolution of animals that once roamed land and transitioned to life in the water. A report on the new discoveries about the reptile, Vadasaurus herzogi, appears online in the Nov. 8 issue of Royal Society Open Science, and suggests that some of the foot-long animal’s features, including its elongated, whip-like tail, and triangular-shaped head, are well suited to aquatic life, while its relatively large limbs link it to land-loving species. … Continue reading

Lab Resources


The ICTR laboratories provide coordinated help across several related programs, all focused on the foundational components required to effectively translate new drugs, biologics, vaccines, devices, biomarkers and diagnostics into clinical trials and eventually clinical practice.

Metabolomics Program


The Metabolomics Program: Provides consultation to basic, clinical, and translational research teams regarding the feasibility, design, and costs of projects using metabolomics technologies (including mass spec and NMR-based metabolomics); Customizes metabolic approaches based on specific research projects/questions: ranging from simple assays to high-throughput approaches such as global metabolic profiling and stable isotope-13C, 15N-labeled on a wide variety of sample types; Provides extensive data analysis and suggest options for subsequent steps towards clinical implementation.   Click here to submit an ICTR Connection Request

Imaging Translational Program


The Imaging Translational Technology Core (Imaging TTC) facilitates one-on-one consultation with imaging experts for study design, imaging protocol development and study implementation. The core facilitates integrated use of imaging resources in translational projects and clinical trials and offers research imaging management infrastructure through the Johns Hopkins Medical Image Research Archive Center for research data storage and distribution Imaging also offers CORIS, a one week observership program for anyone interested in radiology. Participants have an opportunity to shadow Katarzyna (Kasia) J. Macura, MD, PhD, FACR, Professor of Radiology, Urology and Oncology. For more information and to schedule a time, contact Atefeh Ameri at … Continue reading

Proteomic Biomarker Development Program


Proteomics Facility couples mass spectrometry to one and two dimensional separations by column chromatography or gel electrophoresis to identify, quantify or characterize proteins and their post-translational modifications, that are present in complex protein extracts or isolated in solution, gel bands or spots from cells, tissues or body fluids. Metabolite profiling for small molecules from clinical samples Provides biomarker development support Marker verification, validation, qualification for clinical implementation Provides technology and analysis to maximizes coverage of key proteomes required for discovery Quantitative protein analysis methods including mass spectrometry and development of new technologies Click here to submit an ICTR Connection Request

Biologics Translational Program


This lab offers: Biologic product development and testing Consultative support for biologic development Preclinical testing to clinical production for early phase clinical testing Good Manufacturing Practices (GMP) facility and expertise to produce and maintain (stability testing Cell lines Gene vectors Antibodies Peptides   Click here to submit an ICTR Connection Request

Medicinal Chemistry Unit


The Medicinal Chemistry Unit synthesizes small molecule when it is not commercially available.  This unit also supports structure-activity relationship studies. For more information, contact David Meyers, PhD.   Click here to submit an ICTR Connection Request

Genetics Translational Technology Program


The Genetics Translational Technology Program bridges the gap between clinical genetic testing and research-driven molecular technologies with consulting and laboratory services and assistance with translation of molecular technologies to the clinical environment. The program provides: A consultation for the development and conduct of genetic based sequencing and diagnostic assays for clinical testing Clinical assay development services Exome and whole genome sequencing using next generation sequencing (NGS) technologies Partnership with the Kennedy Krieger Institute’s Cytogenetics Laboratory for SNP Array Analysis   Click here to submit an ICTR Connection Request  

Cardiovascular Imaging Laboratory


The Cardiovascular Imaging Laboratory is located at the Bayview CRU and is supervised by Pamela Ouyang, MBBS, ICTR Deputy Director and Director of the Johns Hopkins Women’’s Cardiovascular Health Center. The Core provides echocardiographic and carotid imaging for approved CRU protocols, as well as measurement of endothelial function and arterial stiffness. The Cardiovascular Imaging Laboratory provides the following services and equipment: Echocardiogram Echocardiograms are performed on a Toshiba Artida ultrasound system. All cardiac studies are stored digitally and analyzed using the Philips Excelera System. Image acquisition and analysis protocols can be customized to meet the unique needs of the investigator. … Continue reading

Clinical Research Unit Core Laboratory


The Clinical Research Unit Core Laboratory is housed in the Asthma and Allergy Center at the Bayview Medical Campus. The Core also includes a Sample Processing Laboratory located in the Bayview CRU on the fourth floor of the 301 Building. Directed by Neal Fedarko, PhD, a professor in the Division of Geriatric Medicine and Gerontology, the laboratory offers 87 distinct assays of clinical chemical endpoints and biomarkers to support ICTR research protocols. It is designed to serve ICTR investigators at all CRU locations. The ICTR CRU Core Laboratory supports ICTR-approved protocols by providing facilities, technical experience, and training for non-routine … Continue reading