Tag Archive: Clinical Trial

Celebrate Clinical Trials Day, Monday May 21


The Association of Clinical Research Professionals each Clinical Trials Day helps raise clinical trial awareness and honors clinical research professionals by recognizing their contributions to public health and medical progress. Clinical Trials Day is celebrated around the world each May to recognize the day that James Lind started what is often considered the first randomized clinical trial aboard a ship on May 20, 1747. HERE’S THE STORY* May 1747. The HMS Salisbury of Britain’s Royal Navy fleet patrols the English Channel at a time when scurvy is thought to have killed more British seamen than French and Spanish arms. Aboard … Continue reading

ICTR in the News: Recordings Reveal Deep Credibility Gap When Doctors And Parents Discuss Outcomes For Critically Ill Infants


The following article profiles work performed by ICTR researcher Renee Denise Boss, M.D., associate professor of pediatrics at the Johns Hopkins University School of Medicine. An analysis of 16 audiotaped conversations between parents of infants in a neonatal intensive care unit (NICU) and clinicians found that medical staff routinely downplay quality of life issues and leave families more optimistic about their babies’ prognoses than the clinicians intended. A report of the analysis, published in the Nov. issue of the Journal of Perinatology, highlights a persistent gap between family and clinician understanding of infant outcomes, and the need for clearer communications … Continue reading

ICTR in the News: Bioethicists Call For Caution in Use of Rare Experimental Fetal Therapy


The following article profiles work performed by ICTR researcher Jeremy Sugarman, Harvey M. Meyerhoff Professor of Bioethics and Medicine at the Johns Hopkins University School of Medicine and the deputy director for medicine of the Berman Institute of Bioethics at The Johns Hopkins University. Citing uncertainties about the risks and benefits of an experimental therapy for fetuses whose kidneys do not develop, bioethicists at Johns Hopkins and a team of medical experts are calling for rigorous clinical trials in the use of a potential treatment, known as amnioinfusion. The article, published ahead of print in Obstetrics & Gynecology, calls for … Continue reading

Combination Strategy Could Hold Promise for Ovarian Cancer


Johns Hopkins Kimmel Cancer Center researchers demonstrated that mice with ovarian cancer that received drugs to reactivate dormant genes along with other drugs that activate the immune system had a greater reduction of tumor burden and significantly longer survival than those that received any of the drugs alone. The study has already spurred a clinical trial in ovarian cancer patients. The investigators, led by graduate student Meredith Stone, Ph.D.; postdoctoral fellow Kate Chiappinelli, Ph.D.; and senior author Cynthia Zahnow, Ph.D., believe it could lead to a new way to attack ovarian cancer by strengthening the body’s natural immune response against … Continue reading

Center for Clinical Trials Study Design Consulting Service


The ICTR provides members of the Johns Hopkins research community a consulting service on questions relating to study design and conduct of clinical trials, and meta-analysis of clinical trials. Faculty of the Center for Clinical Trials and Evidence Synthesis (CCTES) are available to meet with researchers to discuss their proposed research plan. Housed in the Department of Epidemiology in the Bloomberg School of Public Health, the interschool CCTES is dedicated to the promotion of clinical trials as a method of evaluation of treatments for health problems. The mission of the consulting service is to provide intellectual and methodological input into clinical … Continue reading

Lab Resources


The ICTR laboratories provide coordinated help across several related programs, all focused on the foundational components required to effectively translate new drugs, biologics, vaccines, devices, biomarkers and diagnostics into clinical trials and eventually clinical practice.

Johns Hopkins Clinical Research Network (JHCRN)


The Johns Hopkins Clinical Research Network (JHCRN), founded in 2009, is an integrated network of select academic and community-based medical institutions established within the Johns Hopkins Institute for Clinical and Translational Research. The JHCRN is a regional translational research organization linking a preeminent academic medical center with a diverse network of community based health care delivery systems. We collaborate with both the private and public sector to more rapidly and cost effectively expedite scientific discovery through clinical trials and comparative effectiveness research to improve the care and health of patients. The JHCRN is comprised of the 6 hospitals within Johns Hopkins … Continue reading

Service Request: Center for Clinical Trials Study Design


Through the ICTR, Center for Clinical Trials (CCT) faculty members offer a consulting service on questions relating to study design and conduct. Housed in the Department of Epidemiology in the Bloomberg School of Public Health, the interschool CCT is dedicated to the promotion of clinical trials as a method of evaluation of preventive and therapeutic approaches to health problems. The goal of this consulting service is to provide intellectual and methodological input into clinical research studies and research synthesis initiated by faculty of Johns Hopkins University. Areas Covered by the CCT Consulting Service: CCT Study Design Consulting offers a thorough discussion and … Continue reading

Allegheny Health Network


The Allegheny Health Network (AHN) is a proud member of Highmark Health. Working as an integrated delivery system, AHN leads the region in the future of care delivery. Our clinical footprint includes two quaternary hospitals, five community hospitals, four health + wellness pavilions, and hundreds of primary and specialty care offices, with more than 1,700 physicians, 17,000 employees, and 2,000 volunteers. AHN, consistently ranked as a national leader in the healthcare industry, is committed to improving health and promoting wellness in our community, one person at a time. We are dedicated to continually learning and exploring new, better, and creative … Continue reading

Project DIDACT


The purpose of this project is to Disseminate, to the clinical and translational research community, Innovative statistical methods and software for the Design and Analysis of Clinical Trials. This joint effort among doctors Miguel Hernan (Harvard), David Kent (Tufts), Kelley Kidwell (Michigan), Michael Rosenblum (Johns Hopkins), Daniel Scharfstein (Johns Hopkins) and Ravi Varadhan, will create a cutting edge analytic tool kit needed to support the next generation of trials. Topics will include: Sequential, multiple assignment randomized trial (SMART) designs (Kidwell) Leveraging baseline covariates to improve the efficiency of randomized trials (Rosenblum) Casual analysis of pragmatic trials (Hernan) Sensitivity analysis for randomized trials … Continue reading

SOM Discovery Fund for Synergy & Innovation Awards


The Discovery Innovation Awards are designed to provide seed funding to support bold, innovative projects to enable new scientific directions and achievements of the highest quality and impact. All school of medicine faculty members are eligible for Innovation Awards of one-year funding of up to $50,000. Synergy Awards consist of one-year funding of up to $100,000 granted to research projects led by full-time, tenure track academic faculty. 2017- 2018 Awardees 2016- 2017 Awardees 2015- 2016 Awardees