Tag Archive: clinical trial

Celebrate Clinical Trials Day, Monday May 21


The Association of Clinical Research Professionals each Clinical Trials Day helps raise clinical trial awareness and honors clinical research professionals by recognizing their contributions to public health and medical progress. Clinical Trials Day is celebrated around the world each May to recognize the day that James Lind started what is often considered the first randomized clinical trial aboard a ship on May 20, 1747. HERE’S THE STORY* May 1747. The HMS Salisbury of Britain’s Royal Navy fleet patrols the English Channel at a time when scurvy is thought to have killed more British seamen than French and Spanish arms. Aboard … Continue reading

ICTR in the News: Recordings Reveal Deep Credibility Gap When Doctors And Parents Discuss Outcomes For Critically Ill Infants


The following article profiles work performed by ICTR researcher Renee Denise Boss, M.D., associate professor of pediatrics at the Johns Hopkins University School of Medicine. An analysis of 16 audiotaped conversations between parents of infants in a neonatal intensive care unit (NICU) and clinicians found that medical staff routinely downplay quality of life issues and leave families more optimistic about their babies’ prognoses than the clinicians intended. A report of the analysis, published in the Nov. issue of the Journal of Perinatology, highlights a persistent gap between family and clinician understanding of infant outcomes, and the need for clearer communications … Continue reading

ICTR in the News: Bioethicists Call For Caution in Use of Rare Experimental Fetal Therapy


The following article profiles work performed by ICTR researcher Jeremy Sugarman, Harvey M. Meyerhoff Professor of Bioethics and Medicine at the Johns Hopkins University School of Medicine and the deputy director for medicine of the Berman Institute of Bioethics at The Johns Hopkins University. Citing uncertainties about the risks and benefits of an experimental therapy for fetuses whose kidneys do not develop, bioethicists at Johns Hopkins and a team of medical experts are calling for rigorous clinical trials in the use of a potential treatment, known as amnioinfusion. The article, published ahead of print in Obstetrics & Gynecology, calls for … Continue reading

Combination Strategy Could Hold Promise for Ovarian Cancer


Johns Hopkins Kimmel Cancer Center researchers demonstrated that mice with ovarian cancer that received drugs to reactivate dormant genes along with other drugs that activate the immune system had a greater reduction of tumor burden and significantly longer survival than those that received any of the drugs alone. The study has already spurred a clinical trial in ovarian cancer patients. The investigators, led by graduate student Meredith Stone, Ph.D.; postdoctoral fellow Kate Chiappinelli, Ph.D.; and senior author Cynthia Zahnow, Ph.D., believe it could lead to a new way to attack ovarian cancer by strengthening the body’s natural immune response against … Continue reading

Lab Resources


The ICTR laboratories provide coordinated help across several related programs, all focused on the foundational components required to effectively translate new drugs, biologics, vaccines, devices, biomarkers and diagnostics into clinical trials and eventually clinical practice.

Service Request: Center for Clinical Trials Study Design


Through the ICTR, Center for Clinical Trials (CCT) faculty members offer a consulting service on questions relating to study design and conduct. Housed in the Department of Epidemiology in the Bloomberg School of Public Health, the interschool CCT is dedicated to the promotion of clinical trials as a method of evaluation of preventive and therapeutic approaches to health problems. The goal of this consulting service is to provide intellectual and methodological input into clinical research studies and research synthesis initiated by faculty of Johns Hopkins University. Areas Covered by the CCT Consulting Service: CCT Study Design Consulting offers a thorough discussion and … Continue reading

Research Participant Recruitment & Retention Support


The Participant Recruitment & Retention Program of the Johns Hopkins Institute for Clinical and Translational Research, established in 2007, offers investigators and research teams training, consultations and a toolkit of evidence-based, field-tested recruitment practices. Services have been developed and offered in collaboration with experts in information technology, ethics, and patient and community-engagement. Each year, workshops, hands on seminars, and customized support are provided to help researchers achieve their recruitment goals. Since its formation, over 1000 investigators and research teams have received recruitment training and support. This includes a broad range of federally funded, multi-site clinical trials and research programs funded … Continue reading