Tag Archive: Clinical Research Unit

Neurological and Behavioral Sciences


Advances in the neurological and behavioral sciences continue to offer unprecedented opportunities to better understand and treat disorders of the central nervous system. The goal of the Neurobehavioral Research Unit (NBRU), located on the Broadway (main medical) campus of the Kennedy Krieger Institute (KKI), is to support research focused on typical and atypical development of the central nervous system, as well as conditions affecting central nervous system functioning throughout the lifespan. Capabilities include neuroimaging, neurogenetic analysis, and neurobehavioral assessment, all of which complement the other vast resources of Hopkins Medicine.NBRU resources are organized into the following components: Brain Research Neurobehavioral Research Neurogenetic … Continue reading

ICTR in the News: Recordings Reveal Deep Credibility Gap When Doctors And Parents Discuss Outcomes For Critically Ill Infants


The following article profiles work performed by ICTR researcher Renee Denise Boss, M.D., associate professor of pediatrics at the Johns Hopkins University School of Medicine. An analysis of 16 audiotaped conversations between parents of infants in a neonatal intensive care unit (NICU) and clinicians found that medical staff routinely downplay quality of life issues and leave families more optimistic about their babies’ prognoses than the clinicians intended. A report of the analysis, published in the Nov. issue of the Journal of Perinatology, highlights a persistent gap between family and clinician understanding of infant outcomes, and the need for clearer communications … Continue reading

Research Coordinator Support Service


The ICTR Research Coordinator Support Service (RCSS) is a pool of research coordinators that are available for hire on a part-time basis by Johns Hopkins researchers. These coordinators are able to handle a wide range of responsibilities, and the support can be customized to best fit the needs to each individuals’ research team.  The pool consists of study coordinator apprentices who are a part of the Study Coordinator Apprenticeship and Mentoring Program (SCAMP) and Research Coordinators. These coordinators are available as part of a fee for service program, which makes the process of finding a part-time coordinator easier, as well … Continue reading

Service Request: Clinical Research Unit (CRU) Online


All investigators must submit an application to a Johns Hopkins Institutional Review Board (IRB) before beginning their ICTR Clinical Research Units (CRUs) application. There are two ways to submit an application to the ICTR Clinical Research Units (CRUs)– one method applies if you are using the School of Medicine eIRB system, while the second applies if you have submitted to another Johns Hopkins IRB. Please read through the materials below. First method: For investigators who apply to the School of Medicine IRB through eIRB. Begin by submitting an IRB application via the eIRB. When completing your application, you MUST answer “Yes” to … Continue reading

Service Request: Biostatistics


Submit Request & Join Our Listserv All CRU protocols are reviewed by a member of the Biostatistics Core prior to approval, and consultations with a Core biostatistician are strongly encouraged for all investigators who do not already have biostatistical support as part of their funded protocols. In conjunction with the Biostatistics Center, ICTR offers researchers access to a research-related consulting service. The goal of the service is to promote the appropriate use of biostatistics in the design, implementation, and interpretation of clinical and translational research studies. The Biostatistics Center supports JHU faculty with primary appointments by providing a maximum of 5 … Continue reading

Future Charges For Clinical Research Unit Services


Effective May 2018 The National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH), which supports the ICTR Clinical Research Units (CRUs) through its Clinical and Translational Science Award (CTSA) program, announced in 2014 that direct support of the CRUs will not be allowed for any new or re-competing CTSA awards.  Our CRUS have been a major source of support for investigators throughout Johns Hopkins and this change in policy will have a significant impact on our future ICTR operations.  This NCATS policy has already been implemented for the 18 CTSA “hubs” that received a new award … Continue reading

Pediatric Neuropsychological Testing


Neuropsychological testing, includes achievement tests, behavior checklists, measures of personality, developmental status, intelligence, executive function, language, visual spatial skills, and memory, are available to ICTR CRU investigators. Skilled psychologists are available to provide a broad range of testing, including assessments of children who are cognitively very limited; those less severely impaired; and learning disabled children and adults; and control groups.

Neuroimaging


Neuroimaging resources available through the NBRU include structural and functional magnetic resonance imaging, spectroscopic and diffusion analysis, fiber track mapping, fMRI protocol development, and training of pediatric and brain/behavior disordered subjects to cooperate with research protocols including motion control during scans. The F.M. Kirby Research Center for Functional Brain Imaging is dedicated to brain research using functional MRI technologies and is specifically designed to provide a uniquely comfortable scanning environment for studies in children, the elderly, and subjects with neurological and psychiatric disorders.

Operant Performance Measures


State-of-the-art Operant Performance Measures are available to investigators through the NBRU at Kennedy Krieger Institute. Direct observation of behavior, conducted in areas that simulate naturalistic settings, is accomplished by the use of computers with accompanying customized software that allows for the simultaneous recording of up to twenty behaviors for real time analysis, including conditional probability calculations.

Pediatric Motion Analysis Laboratory


The Pediatric Motion Analysis Laboratory is available through the NBRU in the Kennedy Krieger Institute. The lab provides whole-body movement assessments that quantify discrete components of the mechanisms of movement and movement deficits and detect very small changes in performance over time or in response to treatment. Several techniques are used to quantify movement, including: three-dimensional tracking and reconstruction of movement kinematics, force plate recordings, recordings of muscle activity, and calculation of joint forces and torques.

Research Participant Advocacy


Research Participant Advocacy (RPA) Program The RPA serves as a resource to volunteers. Contact us for an independent witness to the consent process, to serve on the volunteers behalf in the case of a misunderstanding between the volunteer and study team, or to provide information about research in general or a specific protocol. The Research Participant Advocacy Office provides consulting expertise on human subjects and regulatory issues, including IRB applications, the informed consent process, study feasibility and good clinical practice (GCP). Contact us for quick expert help. The RPA reviews applications to the Clinical Research Unit to assure high standards … Continue reading