Tag Archive: Clinical Research Unit

Clinical Research Units (CRUs)

The Clinical Research Units (CRUs) provide resources at 3 locations throughout the medical campuses–Johns Hopkins Hospital, the Charlotte R. Bloomberg Children’s Center and the 301 Building on the Johns Hopkins Bayview Medical campus. The CRUs are the safest, most efficient way to perform clinical and translational research and offer an indispensable resource that is widely used and required by our NIH funded investigators. Through protocol review, investigator mentoring, trained nursing staff, protocols performed on the CRUs are planned, vetted, monitored and performed under a similar safety standard to clinical care. All protocols are reviewed for scientific rigor, appropriateness of resources … Continue reading

Charges For Clinical Research Unit Services

Effective May 2018, Clinical Research Units are now operating using a service center model.   The National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH), which supports the ICTR Clinical Research Units (CRUs) through its Clinical and Translational Science Award (CTSA) program, announced in 2014 that direct support of the CRUs will not be allowed for any new or re-competing CTSA awards. Our CRUS have been a major source of support for investigators throughout Johns Hopkins and this change in policy will have a significant impact on our future ICTR operations. Consequently, in May 2018, our … Continue reading

Operant Performance Measures

State-of-the-art Operant Performance Measures are available to investigators through the NBRU at Kennedy Krieger Institute. Direct observation of behavior, conducted in areas that simulate naturalistic settings, is accomplished by the use of computers with accompanying customized software that allows for the simultaneous recording of up to twenty behaviors for real time analysis, including conditional probability calculations.

Research Participant Advocacy

The Research Participant Advocacy Program offers consulting expertise on human subjects and regulatory issues, IRB applications, the informed consent process, study feasibility and good clinical practice (GCP). Our advocates serve as a resource to research teams and research participants by reviewing applications to the Clinical Research Unit to assure high standards for human subjects protections. Contact our team to review consent forms, protocol or data and safety monitoring plans. Advocates Are Available to Provide Information on how to administer the best consent Help with Good Clinical Practice (GCP’s) Assistance on how to report an unanticipated study event Guidance with assembling … Continue reading

Exercise Physiology and Body Composition

These services are offered at the Bayview Clinical Research Unit (CRU) and the Adult Outpatient Unit. The Exercise Physiology and Body Composition Core’s laboratory provides DEXA measurements for body fat, muscle and bone composition, metabolic stress testing, and also supports exercise-training protocols. DEXA scanning is also available on the East Baltimore campus through the Adult Outpatient Unit. Supported studies address issues like exercise testing and training and body composition of patients with chronic health conditions. The Core also provides coronary risk factor assessment and modification for approved users and works closely with CRU Research Nursing, Research Nutrition, and the Research … Continue reading

Research Nutrition

If you are an investigator who would like to learn more about how to incorporate ICTR Research Nutrition support into your study, please contact the research nutrition manager as early as possible in your protocol development process. About Us ICTR Research Nutrition was established to support CRU investigators in developing and implementing the best nutritional plans for their research protocols for both pediatrics and adults. Services are located in the clinical research units at both the Johns Hopkins Bayview Campus and the Broadway (main medical) Campus. Research Nutrition staff includes a diverse nutrition team comprised of a research nutrition manager, research … Continue reading

We analyze the 24-hour recalls and food records using Nutrition Data System for Research (NDSR).

Nutrition Education

We provide diet counseling and nutrition education for numerous protocols that involve weight loss, food allergies, chronic diseases including diabetes and cardiovascular disease, and a wide range of rare metabolic disorders for both pediatrics and adults.

Anthropometrics and Body Composition

We offer several non-invasive techniques to measure body composition, including:

  • Height and weight,
  • Circumference measurements like waist, hip, head, thigh, and mid-arm,
  • Skinfold measurements to estimate percentage of body fat, arm muscle area, and arm fat area,
  • Bioelectrical Impedance Analysis (BIA): A small current is passed through the body to estimate body fat mass (weight and percent), fat-free or lean body mass (weight and percent), and body water.

Energy Assessment

  • Indirect Calorimetry– The metabolic cart calculates energy expenditure (REE), which accounts for 75-95% of total energy expenditure. The remaining 5-25% is highly variable depending on age, sex, size, disease state, and daily activity.
  • Predictive Equations– These equations calculate energy requirements based on height, weight, age, and activity factor. Examples are the Mifflin St. Jeor equation, the Harris-Benedict equation, DRIs, etc.

Visit Meals and Diets

We can provide standard or protocol-specific meals snacks, and formula.

Contact Us

Susan Oh, MS, MPH
Director, Research Nutrition Program
susanoh@jhu.edu | 410-955-5189


Cardiovascular Imaging Laboratory

The Cardiovascular Imaging Laboratory provides echocardiographic and carotid imaging for approved CRU protocols, as well as measurement of endothelial function and arterial stiffness.   Echocardiogram Echocardiograms are performed on a Toshiba Artida ultrasound system. All cardiac studies are stored digitally and analyzed using the Philips Excelera System. Image acquisition and analysis protocols can be customized to meet the unique needs of the investigator. Stress Echocardiography Stress echocardiography is a test that uses ultrasound imaging to evaluate heart function during exercise stress. These exams are performed using a Toshiba Artida ultrasound system by an experience sonographer. A cardiologist will be closely … Continue reading

Clinical Research Unit (CRU) Locations and Services

  Bayview Clinical Research Unit   The ICTR Bayview Clinical Research Unit (Bayview CRU) is located on the 4th Floor of 301 Mason Lord Drive on the Johns Hopkins Bayview campus. Services The 14,300 square-foot Bayview CRU provides full-service outpatient and inpatient facilities, with an emphasis on cardiovascular and sleep studies. Bayview also has strong laboratory core services (Core Laboratory for research assays, Cardiovascular Core, Body Composition Core). Exercise physiology facilities are also available. Nurse Managers Marcie Dawson, MS, RN-BC, NE mdawso13@jhmi.edu 410-550-1882 Linda King, BSN, RN lking26@jhmi.edu 410-550-1880 Pediatric Clinical Research Unit (PCRU)   The PCRU is located on … Continue reading

Clinical Research Unit (CRU) Locations and Services

COVID-19 Outpatient Clinical Research Units   The COVID-19 Outpatient Clinical Research Units are located on the Johns Hopkins Bayview campus and at the Johns Hopkins Health Care & Surgery Center- Green Spring Station, Lutherville (adjacent to Pavillion 3). Johns Hopkins Bayview is located in Southeast Baltimore, exit 59 of Interstate 95 and exit 12 of Interstate 895. The Johns Hopkins Health Care & Surgery Center — Green Spring Station, Lutherville, is located five minutes off the Baltimore Beltway Interstate 695 at the I-83 South/Falls Road exit. Services Research participants who are under investigation or have COVID-19 requiring isolation precautions must … Continue reading

Clinical Research Unit Core Laboratory

The Clinical Research Unit Core Laboratory is housed in the Asthma and Allergy Center at the Bayview Medical Campus. The Core also includes a Sample Processing Laboratory located in the Bayview CRU on the fourth floor of the 301 Building. Directed by Neal Fedarko, PhD, a professor in the Division of Geriatric Medicine and Gerontology, the laboratory offers 87 distinct assays of clinical chemical endpoints and biomarkers to support ICTR research protocols. It is designed to serve ICTR investigators at all CRU locations. The ICTR CRU Core Laboratory supports ICTR-approved protocols by providing facilities, technical experience, and training for non-routine … Continue reading

Biostatistics Core

All Clinical Research Unit protocols are reviewed by a member of the Biostatistics Core prior to approval.   Discussing your project with a member of our staff is strongly encouraged for all investigators who do not already have biostatistical support as part of their funded protocols.   Complimentary Consultation In conjunction with the Biostatistics Center, ICTR offers researchers access to a research-related consulting service. The goal of the service is to promote the appropriate use of biostatistics in the design, implementation, and interpretation of clinical and translational research studies. JHU faculty with primary appointments can receive a maximum of 5 … Continue reading