Tag Archive: Clinical Research Unit

Clinical Research Units


*Please Read: Essential Information Regarding COVID-19 and Clinical Research* The Clinical Research Units (CRUs) provide resources at 3 locations throughout the medical campuses–Johns Hopkins Hospital, the Charlotte R. Bloomberg Children’s Center and the 301 Building on the Johns Hopkins Bayview Medical campus. The CRUs are the safest, most efficient way to perform clinical and translational research and offer an indispensable resource that is widely used and required by our NIH funded investigators. Through protocol review, investigator mentoring, trained nursing staff, protocols performed on the CRUs are planned, vetted, monitored and performed under a similar safety standard to clinical care. All […]

Service Request: Clinical Research Unit (CRU) Online


All investigators must submit an application to a Johns Hopkins Institutional Review Board (IRB) before beginning their ICTR Clinical Research Units (CRUs) application. There are two ways to submit an application to the ICTR Clinical Research Units (CRUs)– one method applies if you are using the School of Medicine eIRB system, while the second applies if you have submitted to another Johns Hopkins IRB. Please read through the materials below. If you need assistance with your budget before you apply, please contact Shernice Madison (smadison@jhu.edu, 410-550-7033) or Nicole Cooper (ncooper2@jhmi.edu, 410-550-1880).   First Method: For investigators who apply to the […]

Charges For Clinical Research Unit Services


Effective May 2018, Clinical Research Units are now operating using a service center model. The National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH), which supports the ICTR Clinical Research Units (CRUs) through its Clinical and Translational Science Award (CTSA) program, announced in 2014 that direct support of the CRUs will not be allowed for any new or re-competing CTSA awards. Our CRUS have been a major source of support for investigators throughout Johns Hopkins and this change in policy will have a significant impact on our future ICTR operations. Consequently, in May 2018, our CRUs […]

Operant Performance Measures


State-of-the-art Operant Performance Measures are available to investigators through the NBRU at Kennedy Krieger Institute. Direct observation of behavior, conducted in areas that simulate naturalistic settings, is accomplished by the use of computers with accompanying customized software that allows for the simultaneous recording of up to twenty behaviors for real time analysis, including conditional probability calculations.

Research Participant Advocacy


The Research Participant Advocacy Program offers consulting expertise on human subjects and regulatory issues, IRB applications, the informed consent process, study feasibility and good clinical practice (GCP). Our advocates serve as a resource to research teams and research participants by reviewing applications to the Clinical Research Unit to assure high standards for human subjects protections. Contact our team to review consent forms, protocol or data and safety monitoring plans. Advocates Are Available to Provide Information on how to administer the best consent Help with Good Clinical Practice (GCP’s) Assistance on how to report an unanticipated study event Guidance with assembling […]

Exercise Physiology and Body Composition


These services are primarily offered at the Bayview Clinical Research Unit (CRU). The Exercise Physiology and Body Composition Core’s laboratory provides DEXA measurements for body fat, muscle and bone composition, metabolic stress testing, and also supports exercise-training protocols. DEXA scanning is also available on the Broadway campus through the Adult Outpatient Unit. Supported studies address issues like exercise testing and training and body composition of patients with chronic health conditions. The Core also provides coronary risk factor assessment and modification for approved users and works closely with CRU Research Nursing, Research Nutrition, and the Research Core Laboratory for sample collection […]

Research Nutrition


If you are an investigator who would like to learn more about how to incorporate ICTR Research Nutrition support into your study, please contact the research nutrition manager as early as possible in your protocol development process. About Us ICTR Research Nutrition was established to support CRU investigators in developing and implementing the best nutritional plans for their research protocols for both pediatrics and adults. Services are located in the clinical research units at both the Johns Hopkins Bayview Campus and the Broadway (main medical) Campus. Research Nutrition staff includes a diverse nutrition team comprised of a research nutrition manager, research […]

We analyze the 24-hour recalls and food records using Nutrition Data System for Research (NDSR).

Nutrition Education

We provide diet counseling and nutrition education for numerous protocols that involve weight loss, food allergies, chronic diseases including diabetes and cardiovascular disease, and a wide range of rare metabolic disorders for both pediatrics and adults.

Anthropometrics and Body Composition

We offer several non-invasive techniques to measure body composition, including:

  • Height and weight,
  • Circumference measurements like waist, hip, head, thigh, and mid-arm,
  • Skinfold measurements to estimate percentage of body fat, arm muscle area, and arm fat area,
  • Bioelectrical Impedance Analysis (BIA): A small current is passed through the body to estimate body fat mass (weight and percent), fat-free or lean body mass (weight and percent), and body water.

Energy Assessment

  • Indirect Calorimetry– The metabolic cart calculates energy expenditure (REE), which accounts for 75-95% of total energy expenditure. The remaining 5-25% is highly variable depending on age, sex, size, disease state, and daily activity.
  • Predictive Equations– These equations calculate energy requirements based on height, weight, age, and activity factor. Examples are the Mifflin St. Jeor equation, the Harris-Benedict equation, DRIs, etc.

Visit Meals and Diets

We can provide standard or protocol-specific meals snacks, and formula.

Contact Us

Susan Oh, MS, MPH
Director, Research Nutrition Program
susanoh@jhu.edu | 410-955-5189

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Cardiovascular Imaging Laboratory


The Cardiovascular Imaging Laboratory provides echocardiographic and carotid imaging for approved CRU protocols, as well as measurement of endothelial function and arterial stiffness.   Echocardiogram Echocardiograms are performed on a Toshiba Artida ultrasound system. All cardiac studies are stored digitally and analyzed using the Philips Excelera System. Image acquisition and analysis protocols can be customized to meet the unique needs of the investigator. Stress Echocardiography Stress echocardiography is a test that uses ultrasound imaging to evaluate heart function during exercise stress. These exams are performed using a Toshiba Artida ultrasound system by an experience sonographer. A cardiologist will be closely […]

Locations


COVID-19 Outpatient Clinical Research Unit The COVID-19 CRU is located at Johns Hopkins Health Care & Surgery Center — Green Spring Station, Lutherville, adjacent to Pavilion 3. This location is conveniently located five minutes off the Baltimore Beltway (Interstate 695) at the I-83 South/Falls Road exit. Research participants who are under investigation or have COVID-19 requiring isolation precautions must be scheduled at the COVID-19 Outpatient CRU, which provides a safe environment for study visits and procedures, including phlebotomy and upper respiratory sampling. The unit features two mini-mobiles, a tent, and two specialized PODS, which have been modified to allow for […]

Clinical Research Unit Core Laboratory


The Clinical Research Unit Core Laboratory is housed in the Asthma and Allergy Center at the Bayview Medical Campus. The Core also includes a Sample Processing Laboratory located in the Bayview CRU on the fourth floor of the 301 Building. Directed by Neal Fedarko, PhD, a professor in the Division of Geriatric Medicine and Gerontology, the laboratory offers 87 distinct assays of clinical chemical endpoints and biomarkers to support ICTR research protocols. It is designed to serve ICTR investigators at all CRU locations. The ICTR CRU Core Laboratory supports ICTR-approved protocols by providing facilities, technical experience, and training for non-routine […]

Biostatistics Program


All Clinical Research Unit protocols are reviewed by a member of the Biostatistics Core prior to approval.   Discussing your project with a member of our staff is strongly encouraged for all investigators who do not already have biostatistical support as part of their funded protocols.   Complimentary Consultation In conjunction with the Biostatistics Center, ICTR offers researchers access to a research-related consulting service. The goal of the service is to promote the appropriate use of biostatistics in the design, implementation, and interpretation of clinical and translational research studies. JHU faculty with primary appointments can receive a maximum of 5 […]