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Computational Biology Consulting

The Computational Biology Consulting Core (CBCC) was created to offer state-of-the-art computational biology services to biomedical researchers at the Johns Hopkins University.


The Core is under the direction of Steven Salzberg and managed by Liliana Florea. It builds on the expertise of faculty in the Center for Computational Biology, using best practices and the latest validated technologies to design solutions targeted to researchers’ needs.

Analytical Services

We offer comprehensive analyses of sequencing data for a variety of genomics and other sequencing-based experiments, some of which are listed below. We can handle most types of sequencing data, including Illumina, PacBio, 454, and Sanger reads, and we have experience with a variety of sequencing protocols (RNA-seq, Chip-seq, whole-genome sequencing, whole-exome sequencing, etc). We use the very latest software, and we can work with you to design custom algorithms and analyses as needed.

Examples of analyses:

  • transcriptome assembly (RNA-seq)
  • differential expression and differential splicing
  • SNP and structural variant detection
  • 16S rRNA analysis
  • WGS microbiome (metagenomic) sequence analysis
  • ChIP-seq analysis
  • genome assembly
  • sequence alignment
  • comparative genomics

For all projects, we can arrange to transfer the data directly from the sequencing facility to our computers. We handle all data storage and computing needs, and we send you results of all analyses.


Prices for individual projects will depend on the size and demands of the project, including the need for designing custom solutions. While we cannot estimate the needs for each type of analysis, some examples are listed here. Please contact us for a more specific solution and pricing for your project. If you are preparing a grant proposal, please allow at least one week for a custom quote and to discuss your specific needs and analyses.