Bayview Clinical Research Unit

The ICTR Bayview Clinical Research Unit (Bayview CRU) is located on the 4th Floor of 301 Mason Lord Drive on the Johns Hopkins Bayview Campus. This unit includes both outpatient space and beds for conducting overnight studies.

The 14,300 square-foot Bayview CRU provides full-service outpatient and inpatient facilities, with an emphasis on cardiovascular and sleep studies. Bayview also has strong laboratory core services (Core Laboratory for research assays, Cardiovascular Core, Body Composition Core). Exercise physiology facilities are also available.

For more information, call 410-550-1850.

Pediatric Clinical Research Unit (PCRU)

The PCRU is located on the ninth floor of the new Charlotte R. Bloomberg Children’s Center on the main medical (E. Baltimore) campus and provides both inpatient and outpatient pediatric care.
The PCRU includes a 7-bed inpatient unit, a 4-room outpatient clinic, a multi-purpose procedure room, pediatric phlebotomy laboratory, spirometry, metabolic formula room, and pediatric sleep lab. Pediatric-oriented nursing support and child life services are also provided.

For more information, call 410-614-6365 or email crus@jhmi.edu.

Broadway Adult Inpatient Unit

The Broadway Adult Inpatient Unit is located on the fifth floor of the Osler building in the Johns Hopkins Hospital on the main medical (E. Baltimore) campus.

The unit provides scheduled access to as many as 14 inpatient research beds on a general medical floor that includes capacity for continuous cardiac monitoring and biological isolation of subjects receiving potentially infectious agents.

A full-time clinical research nurse manager is assisted by Johns Hopkins Hospital staff nurses who are trained in research procedures and attend in-service orientations for all ICTR-supported protocols.

For more information, call 410-955-2760.

Broadway Adult Outpatient Unit

The Broadway Adult Outpatient CRU in located on the third floor of the Carnegie Building of the Johns Hopkins Hospital on the Broadway (main medical) campus.

The unit includes nine full-service exam rooms, two interview rooms, a phlebotomy room, sample processing lab, a -70 &deg F freezer, an infusion center, and a DXA scanner.

Full-time clinic support staff include three registered research nurses, as well as a phlebotomist and technicians. The unit staff assist investigators with protocol specific evaluations as requested (including vital signs, collection and processing of biologic specimens and administration of questionnaires.) Qualified nurses administer protocol guided medications for ICTR-approved protocols.

The unit also offers tutorials on creating research order sets and other study-related paperwork for investigators.

For more information, call 410-955-2760.

Neurobehavioral Research Unit

Advances in the neurological and behavioral sciences continue to offer unprecedented opportunities to better understand and treat disorders of the central nervous system. The goal of the Neurobehavioral Research Unit (NBRU), located on the Broadway (main medical) campus of the Kennedy Krieger Institute (KKI), is to support research focused on typical and atypical development of the central nervous system, as well as conditions affecting central nervous system functioning throughout the lifespan. Capabilities include neuroimaging, neurogenetic analysis, and neurobehavioral assessment, all of which complement the other vast resources of Hopkins Medicine.

NBRU resources are organized into the following components:

Brain Research: The F.M. Kirby Research Center for Functional Brain Imaging provides access to MRI support exclusively for research.   This multi-modal resource includes the full spectrum of neuroimaging capabilities (e.g., functional MRI, diffusion tensor MRI, MR spectroscopic imaging, and computational anatomy), and provides investigators with resources for data acquisition and quantitative analysis. The Center houses two 3.0T MRI systems, one of the only 35 ultra-high field 7.0T MRI systems worldwide, three animal scanners, and the Brain Imaging Library, as well as a simulator (or ‘mock scanner’) that can be used to acclimatize subjects preparing for a scan. In addition, various MRI compatible devices are available to monitor and record physiologic responses.

Neurobehavioral Research: Neurobehavioral assessments include standardized tests, operant performance measures, direct observation and quantification of behavior in simulated home, school, and community settings, and the development of customized assessments. Additionally, the Motion Analysis Laboratory provides whole-body movement assessments that quantify discreet components of the mechanisms of movement and movement deficits and detect very small changes in performance over time or in response to treatment.

Neurogenetic Analysis: Great advances have been made in the development of technologies to study the molecular mechanisms underlying disorders of brain development and functioning, and scientists at KKI/Hopkins have been in the forefront of these advances. The Molecular Biology Core Laboratory facilitates research in this area by providing NBRU investigators an extensive menu of services including, but not limited to, blood processing, lymphoblast cell line establishment and repository services, genomic DNA isolation, gene expression and DNA methylation analysis, and bisulfite sequencing focused explicitly on developmental disorders, complementing other Core resources within the Hopkins community.

Research Design and Implementation: Services are provided to investigators by NBRU staff and by linkages to other KKI based resources. The NBRU Core Staff provides assistance to investigators on the development and implementation of research protocols in the following ways: (1) consultation on research design; (2) design of MRI protocols (e.g. paradigm design, stimulus development, experimental implementation); (3) selection and, if necessary, the design of measures of behaviors and cognitive function; and (4) behavioral training of participants to cooperate with various aspects of a protocol when compliance is expected to be a concern (i.e., for patients with substantial behavioral or cognitive impairments or for very young children).

For more information, email Bridget Johnson at johnsonb@kennedykrieger.org.