ICTR in the News: Johns Hopkins is the First and Only Center in the United States Approved for Living Donor HIV-Positive to HIV-Positive Kidney Transplants

The following article profiles work performed by ICTR researcher Dorry Segev, M.D., Ph.D., associate professor of surgery at the Johns Hopkins University School of Medicine.


Credit: Johns Hopkins Medicine

Johns Hopkins hopes to become the first hospital in the U.S. to perform HIV-positive to HIV-positive organ transplants from living donors.

Potential kidney donors are currently being evaluated. A comprehensive medical and psychological screening and evaluation to identify potential risks is done for any individual who is interested in donating an organ. A previous study led by Dorry Segev, M.D., Ph.D., associate professor of surgery at the Johns Hopkins University School of Medicine, found that long-term mortality was similar or lower for live kidney donors than their counterparts in the general public. Once a donor is identified then a suitable recipient, who is currently on the kidney waiting list, will be selected and the procedures will be scheduled.

“This is an unbelievably exciting time for our hospital and our team, but most importantly, it’s a hopeful time for patients living with HIV and end-stage organ disease. Organ transplantation is actually even more important for patients with HIV, since they die on the waiting list even faster than their HIV-negative counterparts. For these individuals, it can mean a new chance at life and a larger pool of organs,” says Segev.

This advance follows the Johns Hopkins team’s completion of the United States’ first ever HIV-to-HIV liver and kidney transplants from deceased donors in early 2016.

Approximately 122,000 people are on the transplant waiting list in the U.S. at any one time; nearly 96,000 of these are on the kidney waitlist. Thousands die each year, many of whom may have lived had they gotten the organ they needed. Meanwhile, Segev estimates that each year, about 500 to 600 HIV-positive, would-be organ donors had organs that could have saved more than 1,000 people ? if only the medical community was allowed to use the organs for transplant.

The first approved HIV-positive to HIV-positive living donor kidney transplant will take place as soon as a suitable donor is approved and a recipient is successfully identified and prepared.