Center for Clinical Data Analysis Receives 2018 School of Medicine Core Coins Award

Congratulations to our Center for Clinical Data Analysis (CCDA)!

 

With the successful launch of the Core Coins Program several years ago, which has provided investigators opportunities to pursue novel research and acquire preliminary data for new grants, we recently invited school of medicine core facilities to apply for participation in the upcoming 2018 Core Coins Program. Similar to the focus in recent years, the goal of the 2018 Core Coins Program is to support school of medicine investigators through a limited amount of free access to exceptional expertise and technology included in the school of medicine’s core portfolio.

 

We received numerous applications for the 2018 program that underwent review by the School of Medicine’s Research Council Core Subcommittee.  Five core facilities have been awarded 2018 Core Coins. They are:

 

1. ICTR Center for Clinical Data Analysis (CCDA): To offer preliminary, anonymous data for feasibility assessment and grant applications to unfunded junior investigators.  Additionally, the core will expand the capabilities of their new Natural Language Processing (NLP) data extraction projects and offer those services to awardees.

 

2. Genetics Research Core Facility (GRCF): To offer single molecule sequencing on the Oxford Nanopore GridION platform, with a focus on rapid sequence identification, utilizing long reads for improved genome assembly, analysis of full length RNA transcripts from cDNA, direct sequencing of RNA molecules, metagenomic analysis, structural variant detection, copy number detection in complex regions, and support of experimentation where short reads are insufficient.

 

3. Johns Hopkins Drug Discovery (JHDD) Group: To offer chemical synthesis of small molecules when they are not commercially available. The chemical synthesis services include but are not limited to literature compound synthesis, scale-up synthesis (for in vivo studies), and analog synthesis for preliminary structure-activity relationship (SAR) analysis.

 

4.  SKCCC Analytical Pharmacology Shared Resource Core: To offer quantitation of small molecules (i.e., drugs and metabolites) in biological fluids utilizing any of four chromatographic (UPLC or UHPLC) instruments with a UV/Vis detector, triple stage quadruple mass spectrometer, and a QTrap system with ion trap capabilities.

 

5. SKCCC Experimental and Computational Genomics Core (ECGC): To support projects that integrate measurements across different sequencing modalities, either by collecting multiple data types or using publicly available data to supplement data generated by the ECGC. Measurements supported through core coins include ChIPseq, whole exome or whole genome sequencing, and methylation assessment.

 

Our goal now is to make the Core Coins available to you, our school of medicine investigators. Each of these core facilities will announce its own application process for Core Coins in the coming weeks. Please begin to think about how you might utilize the services above to extend your research projects.

 

The Core Coins will be administered using the iLab program through a distinct account provided to you after funds are awarded.  All work funded with Core Coins must be completed within 12 months of the award date. Core Coins are not renewable, transferable or eligible for extension beyond 12 months. You will be asked to provide a brief report of the experience, the data and the outcomes in terms of grant proposals submitted.  This information will be needed at the one-year point after Core Coins are awarded.

 

We are excited to announce this year’s Core Coins funding and believe it will extensively contribute to the research mission at Johns Hopkins. Should you have any questions about the program, please contact Shawn Franckowiak (sfrancko@jhmi.edu), director of the Office for Faculty Research Resources.

 

Sincerely,

 

Dan Arking, Ph.D.

Core Subcommittee Chair: SOM Research Council

 

Antony Rosen, M.B.Ch.B., B.Sc.

Vice Dean for Research

Johns Hopkins University School of Medicine