Our Research

The Johns Hopkins Clinical Research Network’s collection of organizations and clinicians coordinate and support clinical trials that offer researchers the opportunity to collaborate with other purpose-driven researchers to advance and improve the practice of medicine.

The JHCRN conducts research in many disciplines including oncology, diabetes, cardiovascular disease, GI conditions, neurological disorders, and genomics. In addition to clinical trials, the JHCRN sites collaborate with Johns Hopkins physicians in grant applications researching patient outcomes, population health, and innovative device applications to monitor disease. The JHCRN has been very helpful in having JHU investigators obtain NIH, PCORI and foundation funding.

Published Research

Neuman MD, Ellenberg SS, Sieber FE, et al. Regional versus General Anesthesia for Promoting Independence after Hip Fracture (REGAIN): protocol for a pragmatic, international multicentre trial. BMJ Open. 2016;6(11):e013473. Published 2016 Nov 15. doi:10.1136/bmjopen-2016-013473

Tomkovich S, Dejea CM, Winglee K, Drewes JL, Chung L, Housseau F, Pope JL, Gauthier J, Sun X, Mühlbauer M, Liu X, Fathi P, Anders RA, Besharati S, Perez-Chanona E, Yang Y, Ding H, Wu X, Wu S, White JR, Gharaibeh RZ, Fodor AA, Wang H, Pardoll DM, Jobin C, Sears CL. Human colon mucosal biofilms from healthy or colon cancer hosts are carcinogenic. J Clin Invest. 2019 Mar 11;130:1699-1712. doi: 10.1172/JCI124196. eCollection 2019 Mar 11. PubMed PMID: 30855275; PubMed Central PMCID: PMC6436866.

Connolly RM, Fackler MJ, Zhang Z, et al. Tumor and serum DNA methylation in women receiving preoperative chemotherapy with or without vorinostat in TBCRC008. Breast Cancer Res Treat. 2018;167(1):107–116. doi:10.1007/s10549-017-4503-2

Scala E, Patterson BJ, Stavarski DH, Mackay P. Engagement in Research: A Clinical Nurse Profile and Motivating Factors. J Nurses Prof Dev. 2019 May/Jun;35(3):137-143. doi: 10.1097/NND.0000000000000538. PubMed PMID: 30829742.

Everett E, Kane B, Yoo A, Dobs A, Mathioudakis N. A Novel Approach for Fully Automated, Personalized Health Coaching for Adults with Prediabetes: Pilot Clinical Trial. J Med Internet Res. 2018 Feb 27;20(2):e72. doi: 10.2196/jmir.9723. http://www.jmir.org/2018/2/e72/ [PMC free article] [PubMed][Cross Ref]

Zysk A. M., Chen K., Gabrielson E., Tafra L., May Gonzalez E. A., Canner J. K., Schneider E. B., Cittadine A. J., Scott Carney P., Boppart S. A., Tsuchiya K., Sawyer K., Jacobs L. K., “Intraoperative assessment of final margins with a handheld optical imaging probe during breast-conserving surgery may reduce the reoperation rate: Results of a multicenter study,” Ann. Surg. Oncol. 22(10), 3356–3362 (2015).10.1245/s10434-015-4665-2 [PMC free article] [PubMed] [Cross Ref]

Brundage M.D., Smith K.C., Little E.A., Bantug E.T., Snyder C.F. Communicating patient-reported outcome scores using graphic formats: results from a mixed-methods evaluation. Qual. Life Res. 2015;24:2457–2472. [PubMed]

Smith KC, Brundage MD, Tolbert E. , et al. Engaging stakeholders to improve presentation of patient-reported outcomes data in clinical practice. Support Care Cancer. Support Care Cancer 2016; 24 (10) 4149-4157 [PubMed]

Bantug ET, Coles T, Smith KC, et al. Graphical displays of patient-reported outcomes (PRO) for use in clinical practice: what makes a pro picture worth a thousand words? Patient Educ Couns. 2016;99(4):483–490. doi: 10.1016/j.pec.2015.10.027.   [PubMed] [Cross Ref]

Snyder CF, Smith KC, Bantug ET, Tolbert EE, Blackford AL, Brundage MD, PRO Data Presentation Stakeholder Advisory Board What do these scores mean? Presenting patient-reported outcomes data to patients and clinicians to improve interpretability. Cancer. 2017;123:1848–59. doi: 10.1002/cncr.30530.[PMC free article] [PubMed] [Cross Ref]