Category Archive: Child of CRUs

Research Coordinator Support Service


The ICTR Research Coordinator Support Service (RCSS) is a pool of research coordinators that are available for hire on a part-time basis by Johns Hopkins researchers. These coordinators are able to handle a wide range of responsibilities, and the support can be customized to best fit the needs to each individuals’ research team.  The pool consists of study coordinator apprentices who are a part of the Study Coordinator Apprenticeship and Mentoring Program (SCAMP) and Research Coordinators. These coordinators are available as part of a fee for service program, which makes the process of finding a part-time coordinator easier, as well […]

Charges For Clinical Research Unit Services


Effective May 2018, Clinical Research Units are now operating using a service center model. The National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH), which supports the ICTR Clinical Research Units (CRUs) through its Clinical and Translational Science Award (CTSA) program, announced in 2014 that direct support of the CRUs will not be allowed for any new or re-competing CTSA awards. Our CRUS have been a major source of support for investigators throughout Johns Hopkins and this change in policy will have a significant impact on our future ICTR operations. This NCATS policy has already been […]

Pediatric Neuropsychological Testing


Neuropsychological testing, includes achievement tests, behavior checklists, measures of personality, developmental status, intelligence, executive function, language, visual spatial skills, and memory, are available to ICTR CRU investigators. Skilled psychologists are available to provide a broad range of testing, including assessments of children who are cognitively very limited; those less severely impaired; and learning disabled children and adults; and control groups.

Operant Performance Measures


State-of-the-art Operant Performance Measures are available to investigators through the NBRU at Kennedy Krieger Institute. Direct observation of behavior, conducted in areas that simulate naturalistic settings, is accomplished by the use of computers with accompanying customized software that allows for the simultaneous recording of up to twenty behaviors for real time analysis, including conditional probability calculations.

Research Participant Advocacy


The Research Participant Advocacy Program offers consulting expertise on human subjects and regulatory issues, IRB applications, the informed consent process, study feasibility and good clinical practice (GCP). Our advocates serve as a resource to research teams and research participants by reviewing applications to the Clinical Research Unit to assure high standards for human subjects protections. Contact our team to review consent forms, protocol or data and safety monitoring plans. Advocates are available to provide: Information on how to administer the best consent Help with Good Clinical Practice (GCP’s) Assistance on how to report an unanticipated study event Guidance with assembling […]

Exercise Physiology and Body Composition


The Exercise Physiology and Body Composition Core’s laboratory provides DEXA measurements for body fat, muscle and bone composition, metabolic stress testing, and also supports exercise-training protocols. The facilities are located at the Bayview Clinical Research Unit. DEXA scanning is also available on the Broadway campus through the Adult Outpatient Unit. Supported studies address issues like exercise testing and training and body composition of patients with chronic health conditions. The Core also provides coronary risk factor assessment and modification for approved users and works closely with CRU Research Nursing, Research Nutrition, and the Research Core Laboratory for sample collection and processing. […]

Research Nutrition


ICTR Research Nutrition was established to support CRU investigators in developing and implementing the best nutritional plans for their research protocols for both pediatrics and adults. Services are located in the clinical research units at both the Johns Hopkins Bayview Campus and the Broadway (main medical) Campus. Research Nutrition staff includes a diverse nutrition team comprised of a research nutrition manager, research nutritionists, a kitchen supervisor, and research nutrition technicians. The ICTR Research Nutrition staff can perform: In-depth nutrition assessments Diet intake analysis for both macro- and micro-nutrients Nutrition counseling Anthropometric and body composition measurements, Energy expenditure assessments Design and […]

We analyze the 24-hour recalls and food records using Nutrition Data System for Research (NDSR).

Nutrition Education

We provide diet counseling and nutrition education for numerous protocols that involve weight loss, food allergies, chronic diseases including diabetes and cardiovascular disease, and a wide range of rare metabolic disorders for both pediatrics and adults.

Anthropometrics and Body Composition

We offer several non-invasive techniques to measure body composition, including:

  • Height and weight,
  • Circumference measurements like waist, hip, head, thigh, and mid-arm,
  • Skinfold measurements to estimate percentage of body fat, arm muscle area, and arm fat area,
  • Bioelectrical Impedance Analysis (BIA): A small current is passed through the body to estimate body fat mass (weight and percent), fat-free or lean body mass (weight and percent), and body water.

Energy Assessment

  • Indirect Calorimetry– The metabolic cart calculates energy expenditure (REE), which accounts for 75-95% of total energy expenditure. The remaining 5-25% is highly variable depending on age, sex, size, disease state, and daily activity.
  • Predictive Equations– These equations calculate energy requirements based on height, weight, age, and activity factor. Examples are the Mifflin St. Jeor equation, the Harris-Benedict equation, DRIs, etc.

Visit Meals and Diets

We can provide standard or protocol-specific meals snacks, and formula.

-->

Cardiovascular Imaging Laboratory


The Cardiovascular Imaging Laboratory provides echocardiographic and carotid imaging for approved CRU protocols, as well as measurement of endothelial function and arterial stiffness.   Echocardiogram Echocardiograms are performed on a Toshiba Artida ultrasound system. All cardiac studies are stored digitally and analyzed using the Philips Excelera System. Image acquisition and analysis protocols can be customized to meet the unique needs of the investigator. Carotid IMT Carotid imaging is performed on a Toshiba Aplio ultrasound system. Using commercially available state of the art equipment that includes automated border detection, the core lab can accurately measure carotid intima-medial thickness and distensibility. Brachial […]

Locations


Bayview Clinical Research Unit The ICTR Bayview Clinical Research Unit (Bayview CRU) is located on the 4th Floor of 301 Mason Lord Drive on the Johns Hopkins Bayview Campus. This unit includes both outpatient space and beds for conducting overnight studies. The 14,300 square-foot Bayview CRU provides full-service outpatient and inpatient facilities, with an emphasis on cardiovascular and sleep studies. Bayview also has strong laboratory core services (Core Laboratory for research assays, Cardiovascular Core, Body Composition Core). Exercise physiology facilities are also available. For more information, call 410-550-1850. Pediatric Clinical Research Unit (PCRU) The PCRU is located on the ninth […]

Biostatistics Program


Submit Request  & Join Our Listserv All Clinical Research Unit protocols are reviewed by a member of the Biostatistics Core prior to approval, and consultations with a Core biostatistician are strongly encouraged for all investigators who do not already have biostatistical support as part of their funded protocols. In conjunction with the Biostatistics Center, ICTR offers researchers access to a research-related consulting service. The goal of the service is to promote the appropriate use of biostatistics in the design, implementation, and interpretation of clinical and translational research studies. The Biostatistics Center supports JHU faculty with primary appointments by providing a maximum […]

Applying to Use the CRUs


All investigators must submit an application to a Johns Hopkins Institutional Review Board (IRB) before beginning their ICTR Clinical Research Units (CRUs) application. There are two ways to submit an application to the ICTR Clinical Research Units (CRUs)– one method applies if you are using the School of Medicine eIRB system, while the second applies if you have submitted to another Johns Hopkins IRB. Please read through the materials below. If you need assistance with your budget before you apply, please contact Shernice Madison (smadison@jhu.edu, 410-550-7033) or Nicole Cooper (ncooper2@jhmi.edu, 410-550-1880).   First Method: For investigators who apply to the […]