Category Archive: announcement

NCATS Funding Opportunity: Tissue Chip Program


NCATS has issued new funding opportunities through its Tissue Chip for Drug Screening program, including: Tissue Chips for Disease Modeling and Efficacy Testing: Letters of intent are due Oct. 29, 2016, and applications must be submitted by Dec. 13, 2016. Read the full announcement. Tissue Chips in Space: NCATS and the Center for the Advancement of Science in Space (CASIS) are collaborating to use tissue chip technology for translational research at the International Space Station U.S. National Laboratory. Letters of intent are due Nov. 15, 2016, and applications must be submitted by Dec. 15, 2016. Read the full announcement. In […]

ICTR in the News: Acute Respiratory Distress Surviviors


This article features research conducted by Dr. Dale Needham, 2016 Synergy Award recipient.   STUDY IDENTIFIES RISK FACTORS FOR PHYSICAL DECLINE AMONG SURVIVORS OF ACUTE RESPIRATORY DISTRESS SYNDROME –Findings could lead to improved post-hospital therapy A new study by a team of Johns Hopkins researchers found that most survivors of acute respiratory distress syndrome (ARDS) decline physically in the five years after hospital discharge, and those at higher levels of risk of decline are older and had greater medical problems prior to hospitalization for ARDS. The study, summarized in a report published Oct. 1 in Intensive Care Medicine, followed 193 survivors […]

Researchers Study Hirschsprung’s Disease


Noncoding Mutations Disrupt Cooperative Function of ‘Gene Families’ in Rare Genetic Disorder –Finding has implications for other diseases involving multiple genes  Scientists at Johns Hopkins say they are one step closer to understanding the genetic mechanism of a rare, complex multiple-gene disorder called Hirschsprung’s disease. The results of their latest study suggest that many patients develop the disease when multiple mutations in gene regulatory sequences of a specific gene combine to destroy the normal cooperative function of a whole network of genes. The investigators say they expect that similarly dysfunctional gene networks influence the onset and progress of other diseases […]

‘Epigenetic’ Drug May Boost Success Of PARP Inhibitor Treatment For Certain Leukemias And Breast Cancers.


Microscopic images of a breast cancer cell with DNA damage. Left, six hours after treatment with either the epigenetic agent alone or the PARP inhibitor alone. Right, six hours after treatment with both the epigenetic drug and PARP inhibitor. Yellow staining shows trapping of the PARP enzyme at a site of DNA damage. Credit: Stephen B. Baylin, M.D. and Feyruz V. Rassool, Ph.D. Drugs called PARP inhibitors, which sabotage cancer cells’ ability to repair damage to their DNA, have shown some promise in treating human breast cancers that contain BRCA1 and BRCA2 gene mutations. Now, a new study in lab-grown […]

New Treatment Strategy Could Cut Parkinson’s Disease Off At The Pass


–Drug already in clinical trials for other conditions slows disease progression in mice α-synuclein aggregates in the brain cells of mice with (top) and without (bottom) the LAG3 protein. (Credit: Xiaobo Mao) Researchers at Johns Hopkins report they have identified a protein that enables a toxic natural aggregate to spread from cell to cell in a mammal’s brain — and a way to block that protein’s action. Their study in mice and cultured cells suggests that an immunotherapy already in clinical trials as a cancer therapy should also be tested as a way to slow the progress of Parkinson’s disease, […]

The Surprising Thing Blind People Doing Math Reveals About the Brain


Human babies and even animals have a basic number sense that many believe evolves from seeing the world and trying to quantify all the sights. But vision has nothing to do with it – Johns Hopkins University neuroscientists have found that the brain network behind numerical reasoning is identical in blind and sighted people. The researchers also found the visual cortex in blind people is highly involved in doing math, suggesting the brain is vastly more adaptable than previously believed. The findings are set to be published Monday in the journal Proceedings of the National Academy of Sciences. “The number […]

NCATS Funds Feasibility Assessment to Develop Biomedical Data Translator


Scientific experts from 11 institutions are collaborating to assess the feasibility of developing NCATS’ Biomedical Data Translator. The goal is to identify and design innovative tools to integrate and leverage the vast amounts of medical research data currently available. Ultimately, researchers plan to create a ground-breaking, publicly available system that could revolutionize the translational research process and bring more treatments to more patients more quickly. Read the web announcement. Get more details about the projects. Learn more about the Biomedical Data Translator program.

KL2 Clinical Research Mentored Career Development Awards – Deadline 3/2


Applications are being accepted for the Johns Hopkins Clinical Research Scholars KL2 Awards, supporting clinical research training and career development of junior faculty dedicated toward a career in clinical investigation. The deadline to submit your completed application is DECEMBER 2, 2016. We anticipate funding 6 KL2 awards with an appointment date of July 1, 2017 and a 7th award that will begin on September 1, 2017.

NIH Releases Final Rule Governing Mandatory Clinical Trial Registration and Reporting


On Friday, September 16, 2016 the U.S. Department of Health and Human Services (HHS) released the much anticipated Final Rule for clinical trial registration and reporting.  42 CFR Part 11, Clinical Trials Registration and Results Information Submission; Final Rule was added to the Federal Register on Wednesday, September 21, 2016 and will take effect on  January 18, 2017.  A brief summary was also released. The Johns Hopkins Institute for Clinical and Translational Research (ICTR) is committed to the ethical conduct and transparency of research throughout the Institution.  The ClinicalTrials.gov Program, launched earlier this year, has been preparing Principal Investigators and […]

Testosterone May Explain Sex Difference in Knee Injury Rates


–Male rats without testosterone have weaker anterior cruciate ligaments (ACLs) than those with it In studies on rats, Johns Hopkins Medicine scientists report new evidence that the predominance of the hormone testosterone in males may explain why women are up to 10 times more likely than men to injure the anterior cruciate ligament (ACL) in their knees. Specifically, they found that normal male rats with natural supplies of testosterone had stronger ACLs than those that had been castrated and no longer produced the hormone. The results are described online Sept. 20 in the journal The Knee. “The primary implication of […]

ICTR in the News: Adrian Dobs Featured in MD Magazine


This article posted in MD Magazine features Adrian Dobs, MD, MHS, director of the Johns Hopkins Clinical Research Network .    For men who have low or reduced testosterone there can be many reasons for the cause of the condition and can require a variety of treatment methods. A study looked at a new way of delivering testosterone in pill form to help these patients. Adrian Dobs, MD, MHS, John Hopkins University School of Medicine, said the pill form of delivery was a “new, novel” way to administer testosterone for hypogonadism. The condition of hypogonadism could be from primary testicular failure […]