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at 250 × 249 in Researchers Study Hirschsprung’s Disease.

Caption: Mutations in RET’s three enhancers (RET -7, RET -5.5 and RET +3) can disrupt the binding of their transcription factors (RARB, GATA2 and SOX10, respectively) and alter the activation of the RET gene and the production of RET mRNA and protein. (Credit: Cell Press)