NCATS Funding Opportunity: Bench-to-Clinic Repurposing Initiative

NCATS anticipates awarding $3.5 million in fiscal year 2017 to fund up to 10 awards through a new Discovering New Therapeutic Uses for Existing Molecules (New Therapeutic Uses) Bench-to-Clinic Repurposing initiative. The goal is to support investigators to repurpose ― or identify new uses for — existing experimental drugs or biologics as well as Food and Drug Administration-approved therapies.

Specifically, NCATS is seeking applications for pre-clinical (bench) studies to test the effectiveness of using an independent crowdsourcing effort, computational algorithm or big datasets from patient records to predict new uses of a drug or biologic. Based on recently awarded projects through a similar NCATS funding opportunity, the most common strategies for identifying a new therapeutic/indication pair are independent crowdsourcing, cheminformatics, genomic expression, network analysis and phenomic data. Note that use of patient data is a new potential strategy through the current funding opportunity.

Applications Due: Nov. 14, 2016

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