Fecal Microbiome Differences in Ulcerative Colitis Among Chinese Patients

Susan Hutfless, MS, PhD; Daniel Peterson, MD, PhD

Abstract

We propose a translational research project to combine the intellectual momentum of Sun Yat-sen University and Johns Hopkins University to study the impact of migration on the human intestinal and oral microbiomes with respect to Crohn’s disease and ulcerative colitis risk while piloting a new assay to help move microbiome studies from the lab to the bedside. The team will include an epidemiologist trained at Johns Hopkins, an immunopathologist trained in the Gordon lab at Washington University, St. Louis and a gastroenterologist from Sun Yat-sen University. Together we will pursue the goal of studying the human microbiome in a new way by examining dietary, environmental and gut and oral microbiome profiles of Crohn’s disease and ulcerative colitis cases and controls in urban and rural environments. We will also develop a new assay with the potential to measure the microbiome in real-world settings such as gastroenterology clinics.