Timeline

 

Year Entity Event
1997 Congress 1st U.S. law to require trial registration (FDAMA)
2000 NIH Releases ClinicalTrials.gov website
2005 ICMJE Requires registration before enrollment
2006 WHO All clinical trials should be registered
2007 CMS PI must enroll qualifying clinical trials in ClinicalTrials.gov
2007 Congress Expanded registration, submission of results and adverse events, civil penalties (FDAAA)
2008 NIH Releases results database
2015 CMS Mandatory Reporting of Clinical Trial Number on Claims